Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ(1-42) secretion in SH-SY5Y neural cells. [electronic resource]
Producer: 20161213Description: 179-90 p. digitalISSN:- 1538-2443
- AIDS Dementia Complex -- blood
- Adult
- Aged
- Amyloid beta-Peptides -- biosynthesis
- Anti-HIV Agents -- therapeutic use
- Cell Line, Tumor
- Exosomes -- metabolism
- Female
- Gene Expression Regulation
- HEK293 Cells
- HIV-1 -- drug effects
- Humans
- Male
- Middle Aged
- Neurons -- metabolism
- Peptide Fragments -- biosynthesis
- RNA, Messenger -- biosynthesis
- RNA, Viral -- blood
- Viral Load
- nef Gene Products, Human Immunodeficiency Virus -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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