Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237. [electronic resource]
Producer: 20100927Description: 563-76 p. digitalISSN:- 1554-8937
- Animals
- Aurora Kinases
- Azepines -- pharmacology
- Benzazepines -- pharmacology
- Cell Cycle Proteins -- metabolism
- Cell Proliferation -- drug effects
- Crystallography, X-Ray
- Drug Resistance
- HeLa Cells
- Humans
- Microtubule-Associated Proteins -- metabolism
- Models, Molecular
- Mutation
- Nuclear Proteins -- metabolism
- Phosphoproteins -- metabolism
- Protein Binding
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyrimidines -- pharmacology
- Xenopus -- metabolism
- Xenopus Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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