Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. [electronic resource]
Producer: 20180905Description: 190 p. digitalISSN:- 1756-9966
- AMP-Activated Protein Kinase Kinases
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Autophagy -- drug effects
- Autophagy-Related Protein-1 Homolog -- metabolism
- Cell Line, Tumor
- Colonic Neoplasms -- pathology
- Curcumin -- pharmacology
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Fluorouracil -- pharmacology
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Protein Kinases -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication
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