Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. [electronic resource]
Producer: 20071212Description: 30910-9 p. digitalISSN:- 0021-9258
- Androgen Antagonists -- chemical synthesis
- Androgens
- Crystallography, X-Ray
- Dihydrotestosterone -- antagonists & inhibitors
- Gestrinone -- analogs & derivatives
- Gonadal Disorders -- drug therapy
- Humans
- Ligands
- Protein Binding
- Protein Structure, Secondary
- Protein Structure, Tertiary -- physiology
- Receptors, Androgen -- chemistry
- Structure-Activity Relationship
- Transcriptional Activation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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