The benzoxathiolone LYR-71 down-regulates interferon-gamma-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages. [electronic resource]
Producer: 20100312Description: 1971-81 p. digitalISSN:- 1476-5381
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Bone Marrow -- metabolism
- Bridged Bicyclo Compounds, Heterocyclic -- pharmacology
- Cell Line
- Down-Regulation -- drug effects
- Enzyme-Linked Immunosorbent Assay
- Imines -- pharmacology
- Inflammation -- drug therapy
- Interferon-gamma -- metabolism
- Macrophages -- drug effects
- Male
- Mice
- Mice, Inbred C3H
- Nitric Oxide -- metabolism
- Phosphorylation -- drug effects
- STAT1 Transcription Factor -- drug effects
- Tyrosine -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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