Results
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Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors. [electronic resource] by
- Bagley, Scott W
- Southers, James A
- Cabral, Shawn
- Rose, Colin R
- Bernhardson, David J
- Edmonds, David J
- Polivkova, Jana
- Yang, Xiaojing
- Kung, Daniel W
- Griffith, David A
- Bader, Scott J
Producer: 20120605
In:
The Journal of organic chemistry vol. 77
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4.
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Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. [electronic resource] by
- Walker, Daniel P
- Zawistoski, Michael P
- McGlynn, Molly A
- Li, Jian-Cheng
- Kung, Daniel W
- Bonnette, Peter C
- Baumann, Amy
- Buckbinder, Leonard
- Houser, Janet A
- Boer, Jason
- Mistry, Anil
- Han, Seungil
- Xing, Li
- Guzman-Perez, Angel
Producer: 20090821
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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5.
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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). [electronic resource] by
- Ryder, Tim F
- Calabrese, Matthew F
- Walker, Gregory S
- Cameron, Kimberly O
- Reyes, Allan R
- Borzilleri, Kris A
- Delmore, Jake
- Miller, Russell
- Kurumbail, Ravi G
- Ward, Jessica
- Kung, Daniel W
- Brown, Janice A
- Edmonds, David J
- Eng, Heather
- Wolford, Angela C
- Kalgutkar, Amit S
Producer: 20191014
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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6.
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Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. [electronic resource] by
- DeNinno, Michael P
- Wright, Stephen W
- Etienne, John B
- Olson, Thanh V
- Rocke, Benjamin N
- Corbett, Jeffrey W
- Kung, Daniel W
- DiRico, Kenneth J
- Andrews, Kim M
- Millham, Michele L
- Parker, Janice C
- Esler, William
- van Volkenburg, Maria
- Boyer, David D
- Houseknecht, Karen L
- Doran, Shawn D
Producer: 20130107
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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7.
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Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry. [electronic resource] by
- Liu, Chang
- Le Blanc, J C Yves
- Schneider, Bradley B
- Shields, Jefry
- Federico, James J
- Zhang, Hui
- Stroh, Justin G
- Kauffman, Gregory W
- Kung, Daniel W
- Ieritano, Christian
- Shepherdson, Evan
- Verbuyst, Mitch
- Melo, Luke
- Hasan, Moaraj
- Naser, Dalia
- Janiszewski, John S
- Hopkins, W Scott
- Campbell, J Larry
Publication details: ACS central science Feb 2017
In:
ACS central science vol. 3
Availability: No items available.
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8.
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Correction to "Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry". [electronic resource] by
- Liu, Chang
- Le Blanc, J C Yves
- Schneider, Bradley B
- Shields, Jefry
- Federico, James J
- Zhang, Hui
- Stroh, Justin G
- Kauffman, Gregory W
- Kung, Daniel W
- Shapiro, Michael
- Ieritano, Christian
- Shepherdson, Evan
- Verbuyst, Mitch
- Melo, Luke
- Hasan, Moaraj
- Naser, Dalia
- Janiszewski, John S
- Hopkins, W Scott
- Campbell, J Larry
Publication details: ACS central science Apr 2017
In:
ACS central science vol. 3
Availability: No items available.
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9.
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Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. [electronic resource] by
- Griffith, David A
- Kung, Daniel W
- Esler, William P
- Amor, Paul A
- Bagley, Scott W
- Beysen, Carine
- Carvajal-Gonzalez, Santos
- Doran, Shawn D
- Limberakis, Chris
- Mathiowetz, Alan M
- McPherson, Kirk
- Price, David A
- Ravussin, Eric
- Sonnenberg, Gabriele E
- Southers, James A
- Sweet, Laurel J
- Turner, Scott M
- Vajdos, Felix F
Producer: 20150310
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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10.
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Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response. [electronic resource] by
- McClure, Kim F
- Darout, Etzer
- Guimarães, Cristiano R W
- DeNinno, Michael P
- Mascitti, Vincent
- Munchhof, Michael J
- Robinson, Ralph P
- Kohrt, Jeffrey
- Harris, Anthony R
- Moore, Dianna E
- Li, Bryan
- Samp, Lacey
- Lefker, Bruce A
- Futatsugi, Kentaro
- Kung, Daniel
- Bonin, Paul D
- Cornelius, Peter
- Wang, Ruduan
- Salter, Eben
- Hornby, Sam
- Kalgutkar, Amit S
- Chen, Yue
Producer: 20110617
In:
Journal of medicinal chemistry vol. 54
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11.
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Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. [electronic resource] by
- Kung, Daniel W
- Coffey, Steven B
- Jones, Ryan M
- Cabral, Shawn
- Jiao, Wenhua
- Fichtner, Michael
- Carpino, Philip A
- Rose, Colin R
- Hank, Richard F
- Lopaze, Michael G
- Swartz, Roger
- Chen, Hou Tommy
- Hendsch, Zachary
- Posner, Bruce
- Wielis, Christopher F
- Manning, Brian
- Dubins, Jeffrey
- Stock, Ingrid A
- Varma, Sam
- Campbell, Mary
- DeBartola, Demetria
- Kosa-Maines, Rachel
- Steyn, Stefanus J
- McClure, Kim F
Producer: 20121019
In:
Bioorganic & medicinal chemistry letters vol. 22
Availability: No items available.
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12.
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Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase. [electronic resource] by
- Kung, Daniel W
- Griffith, David A
- Esler, William P
- Vajdos, Felix F
- Mathiowetz, Alan M
- Doran, Shawn D
- Amor, Paul A
- Bagley, Scott W
- Banks, Tereece
- Cabral, Shawn
- Ford, Kristen
- Garcia-Irizarry, Carmen N
- Landis, Margaret S
- Loomis, Kathrine
- McPherson, Kirk
- Niosi, Mark
- Rockwell, Kristin L
- Rose, Colin
- Smith, Aaron C
- Southers, James A
- Tapley, Susan
- Tu, Meihua
- Valentine, James J
Producer: 20161216
In:
Bioorganic & medicinal chemistry letters vol. 25
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13.
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From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor. [electronic resource] by
- Futatsugi, Kentaro
- Mascitti, Vincent
- Guimarães, Cristiano R W
- Morishita, Nao
- Cai, Cuiman
- DeNinno, Michael P
- Gao, Hua
- Hamilton, Michael D
- Hank, Richard
- Harris, Anthony R
- Kung, Daniel W
- Lavergne, Sophie Y
- Lefker, Bruce A
- Lopaze, Michael G
- McClure, Kim F
- Munchhof, Michael J
- Preville, Cathy
- Robinson, Ralph P
- Wright, Stephen W
- Bonin, Paul D
- Cornelius, Peter
- Chen, Yue
- Kalgutkar, Amit S
Producer: 20130528
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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14.
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Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2). [electronic resource] by
- Futatsugi, Kentaro
- Kung, Daniel W
- Orr, Suvi T M
- Cabral, Shawn
- Hepworth, David
- Aspnes, Gary
- Bader, Scott
- Bian, Jianwei
- Boehm, Markus
- Carpino, Philip A
- Coffey, Steven B
- Dowling, Matthew S
- Herr, Michael
- Jiao, Wenhua
- Lavergne, Sophie Y
- Li, Qifang
- Clark, Ronald W
- Erion, Derek M
- Kou, Kou
- Lee, Kyuha
- Pabst, Brandon A
- Perez, Sylvie M
- Purkal, Julie
- Jorgensen, Csilla C
- Goosen, Theunis C
- Gosset, James R
- Niosi, Mark
- Pettersen, John C
- Pfefferkorn, Jeffrey A
- Ahn, Kay
- Goodwin, Bryan
Producer: 20151229
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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15.
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Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases. [electronic resource] by
- Ruggeri, Roger B
- Buckbinder, Leonard
- Bagley, Scott W
- Carpino, Philip A
- Conn, Edward L
- Dowling, Matthew S
- Fernando, Dilinie P
- Jiao, Wenhua
- Kung, Daniel W
- Orr, Suvi T M
- Qi, Yingmei
- Rocke, Benjamin N
- Smith, Aaron
- Warmus, Joseph S
- Zhang, Yan
- Bowles, Daniel
- Widlicka, Daniel W
- Eng, Heather
- Ryder, Tim
- Sharma, Raman
- Wolford, Angela
- Okerberg, Carlin
- Walters, Karen
- Maurer, Tristan S
- Zhang, Yanwei
- Bonin, Paul D
- Spath, Samantha N
- Xing, Gang
- Hepworth, David
- Ahn, Kay
- Kalgutkar, Amit S
Producer: 20160225
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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16.
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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor. [electronic resource] by
- McClure, Kim F
- Jackson, Margaret
- Cameron, Kimberly O
- Kung, Daniel W
- Perry, David A
- Orr, Suvi T M
- Zhang, Yingxin
- Kohrt, Jeffrey
- Tu, Meihua
- Gao, Hua
- Fernando, Dilinie
- Jones, Ryan
- Erasga, Noe
- Wang, Guoqiang
- Polivkova, Jana
- Jiao, Wenhua
- Swartz, Roger
- Ueno, Hirokazu
- Bhattacharya, Samit K
- Stock, Ingrid A
- Varma, Sam
- Bagdasarian, Victoria
- Perez, Sylvie
- Kelly-Sullivan, Dawn
- Wang, Ruduan
- Kong, Jimmy
- Cornelius, Peter
- Michael, Laura
- Lee, Eunsun
- Janssen, Ann
- Steyn, Stefanus J
- Lapham, Kimberly
- Goosen, Theunis
Producer: 20140407
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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17.
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Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. [electronic resource] by
- Walker, Daniel P
- Bi, F Christopher
- Kalgutkar, Amit S
- Bauman, Jonathan N
- Zhao, Sabrina X
- Soglia, John R
- Aspnes, Gary E
- Kung, Daniel W
- Klug-McLeod, Jacquelyn
- Zawistoski, Michael P
- McGlynn, Molly A
- Oliver, Robert
- Dunn, Matthew
- Li, Jian-Cheng
- Richter, Daniel T
- Cooper, Beth A
- Kath, John C
- Hulford, Catherine A
- Autry, Christopher L
- Luzzio, Michael J
- Ung, Ethan J
- Roberts, W Gregory
- Bonnette, Peter C
- Buckbinder, Leonard
- Mistry, Anil
- Griffor, Matthew C
- Han, Seungil
- Guzman-Perez, Angel
Producer: 20090109
In:
Bioorganic & medicinal chemistry letters vol. 18
Availability: No items available.
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18.
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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. [electronic resource] by
- Cameron, Kimberly O
- Kung, Daniel W
- Kalgutkar, Amit S
- Kurumbail, Ravi G
- Miller, Russell
- Salatto, Christopher T
- Ward, Jessica
- Withka, Jane M
- Bhattacharya, Samit K
- Boehm, Markus
- Borzilleri, Kris A
- Brown, Janice A
- Calabrese, Matthew
- Caspers, Nicole L
- Cokorinos, Emily
- Conn, Edward L
- Dowling, Matthew S
- Edmonds, David J
- Eng, Heather
- Fernando, Dilinie P
- Frisbie, Richard
- Hepworth, David
- Landro, James
- Mao, Yuxia
- Rajamohan, Francis
- Reyes, Allan R
- Rose, Colin R
- Ryder, Tim
- Shavnya, Andre
- Smith, Aaron C
- Tu, Meihua
- Wolford, Angela C
- Xiao, Jun
Producer: 20170710
In:
Journal of medicinal chemistry vol. 59
Availability: No items available.
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19.
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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). [electronic resource] by
- Edmonds, David J
- Kung, Daniel W
- Kalgutkar, Amit S
- Filipski, Kevin J
- Ebner, David C
- Cabral, Shawn
- Smith, Aaron C
- Aspnes, Gary E
- Bhattacharya, Samit K
- Borzilleri, Kris A
- Brown, Janice A
- Calabrese, Matthew F
- Caspers, Nicole L
- Cokorinos, Emily C
- Conn, Edward L
- Dowling, Matthew S
- Eng, Heather
- Feng, Bo
- Fernando, Dilinie P
- Genung, Nathan E
- Herr, Michael
- Kurumbail, Ravi G
- Lavergne, Sophie Y
- Lee, Esther C-Y
- Li, Qifang
- Mathialagan, Sumathy
- Miller, Russell A
- Panteleev, Jane
- Polivkova, Jana
- Rajamohan, Francis
- Reyes, Allan R
- Salatto, Christopher T
- Shavnya, Andre
- Thuma, Benjamin A
- Tu, Meihua
- Ward, Jessica
- Withka, Jane M
- Xiao, Jun
- Cameron, Kimberly O
Producer: 20190417
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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