Influence of CYP2C9 polymorphisms on the pharmacokinetics and cholesterol-lowering activity of (-)-3S,5R-fluvastatin and (+)-3R,5S-fluvastatin in healthy volunteers. [electronic resource]
Producer: 20030828Description: 186-94 p. digitalISSN:- 0009-9236
- Adult
- Amino Acid Substitution
- Anticholesteremic Agents -- adverse effects
- Aryl Hydrocarbon Hydroxylases -- genetics
- Cholesterol -- blood
- Cholesterol, HDL -- blood
- Cholesterol, LDL -- blood
- Cytochrome P-450 CYP2C9
- DNA, Complementary -- genetics
- Fatty Acids, Monounsaturated -- adverse effects
- Female
- Fluvastatin
- Genotype
- Humans
- Indoles -- adverse effects
- Male
- Middle Aged
- Polymorphism, Genetic -- physiology
- Pyridines -- pharmacokinetics
- Stereoisomerism
- Triglycerides -- blood
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Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
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