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High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. [electronic resource] by
- Fradera, Xavier
- Kazemier, Bert
- Carswell, Emma
- Cooke, Andrew
- Oubrie, Arthur
- Hamilton, William
- Dempster, Maureen
- Krapp, Stephan
- Nagel, Susanna
- Jestel, Anja
Producer: 20120625
In:
Acta crystallographica. Section F, Structural biology and crystallization communications vol. 68
Availability: No items available.
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8.
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Design of selective Cathepsin inhibitors. [electronic resource] by
- Bethel, Paul A
- Gerhardt, Stefan
- Jones, Emma V
- Kenny, Peter W
- Karoutchi, Galith I
- Morley, Andrew D
- Oldham, Keith
- Rankine, Neil
- Augustin, Martin
- Krapp, Stephan
- Simader, Hannes
- Steinbacher, Stefan
Producer: 20091013
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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9.
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β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site. [electronic resource] by
- Zheng, Jianbin
- Chen, Long
- Skinner, Owen S
- Ysselstein, Daniel
- Remis, Jonathan
- Lansbury, Peter
- Skerlj, Renato
- Mrosek, Michael
- Heunisch, Ursula
- Krapp, Stephan
- Charrow, Joel
- Schwake, Michael
- Kelleher, Neil L
- Silverman, Richard B
- Krainc, Dimitri
Producer: 20180622
In:
Journal of the American Chemical Society vol. 140
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10.
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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition. [electronic resource] by
- Dossetter, Alexander G
- Bowyer, Jonathan
- Cook, Calum R
- Crawford, James J
- Finlayson, Jonathan E
- Heron, Nicola M
- Heyes, Christine
- Highton, Adrian J
- Hudson, Julian A
- Jestel, Anja
- Krapp, Stephan
- MacFaul, Philip A
- McGuire, Thomas M
- Morley, Andrew D
- Morris, Jeffrey J
- Page, Ken M
- Ribeiro, Lyn Rosenbrier
- Sawney, Helen
- Steinbacher, Stefan
- Smith, Caroline
Producer: 20130107
In:
Bioorganic & medicinal chemistry letters vol. 22
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Dipeptidyl nitrile inhibitors of Cathepsin L. [electronic resource] by
- Asaad, Nabil
- Bethel, Paul A
- Coulson, Michelle D
- Dawson, Jack E
- Ford, Susannah J
- Gerhardt, Stefan
- Grist, Matthew
- Hamlin, Gordon A
- James, Michael J
- Jones, Emma V
- Karoutchi, Galith I
- Kenny, Peter W
- Morley, Andrew D
- Oldham, Keith
- Rankine, Neil
- Ryan, David
- Wells, Stuart L
- Wood, Linda
- Augustin, Martin
- Krapp, Stephan
- Simader, Hannes
- Steinbacher, Stefan
Producer: 20091207
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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12.
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Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors. [electronic resource] by
- Crawford, James J
- Kenny, Peter W
- Bowyer, Jonathan
- Cook, Calum R
- Finlayson, Jonathan E
- Heyes, Christine
- Highton, Adrian J
- Hudson, Julian A
- Jestel, Anja
- Krapp, Stephan
- Martin, Scott
- Macfaul, Philip A
- McDermott, Benjamin P
- McGuire, Thomas M
- Morley, Andrew D
- Morris, Jeffrey J
- Page, Ken M
- Ribeiro, Lyn Rosenbrier
- Sawney, Helen
- Steinbacher, Stefan
- Smith, Caroline
- Dossetter, Alexander G
Producer: 20130205
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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13.
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(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. [electronic resource] by
- Dossetter, Alexander G
- Beeley, Howard
- Bowyer, Jonathan
- Cook, Calum R
- Crawford, James J
- Finlayson, Jonathan E
- Heron, Nicola M
- Heyes, Christine
- Highton, Adrian J
- Hudson, Julian A
- Jestel, Anja
- Kenny, Peter W
- Krapp, Stephan
- Martin, Scott
- MacFaul, Philip A
- McGuire, Thomas M
- Gutierrez, Pablo Morentin
- Morley, Andrew D
- Morris, Jeffrey J
- Page, Ken M
- Ribeiro, Lyn Rosenbrier
- Sawney, Helen
- Steinbacher, Stefan
- Smith, Caroline
- Vickers, Madeleine
Producer: 20121009
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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