Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. [electronic resource]
Producer: 20020122Description: 177-88 p. digitalISSN:- 0022-2623
- 3T3 Cells
- Alkyl and Aryl Transferases -- antagonists & inhibitors
- Animals
- Blotting, Western
- Crystallography, X-Ray
- Enzyme Inhibitors -- chemical synthesis
- Genes, ras
- Hydrophobic and Hydrophilic Interactions
- Mice
- Molecular Mimicry
- Oligopeptides -- chemistry
- Protein Prenylation
- Stereoisomerism
- Structure-Activity Relationship
- Zinc -- chemistry
- rap1 GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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