Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1. [electronic resource]
Producer: 20111128Description: e182 p. digitalISSN:- 2041-4889
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- drug effects
- Binding Sites
- Cell Line, Tumor
- Computer Simulation
- Cyclin-Dependent Kinase 9 -- antagonists & inhibitors
- Flavanones -- therapeutic use
- Flavones -- therapeutic use
- Humans
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasms -- drug therapy
- Phosphorylation
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- RNA Interference
- RNA Polymerase II -- antagonists & inhibitors
- RNA, Small Interfering -- metabolism
- Scutellaria baicalensis -- chemistry
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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