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Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure. [electronic resource] by
- Ceccarelli, Simona M
- Jaeschke, Georg
- Buettelmann, Bernd
- Huwyler, Jörg
- Kolczewski, Sabine
- Peters, Jens-Uwe
- Prinssen, Eric
- Porter, Richard
- Spooren, Will
- Vieira, Eric
Producer: 20070515
In:
Bioorganic & medicinal chemistry letters vol. 17
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Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists. [electronic resource] by
- Kolczewski, Sabine
- Adam, Geo
- Cesura, Andrea M
- Jenck, François
- Hennig, Michael
- Oberhauser, Thomas
- Poli, Sonia M
- Rössler, Felix
- Röver, Stephan
- Wichmann, Jürgen
- Dautzenberg, Frank M
Producer: 20030204
In:
Journal of medicinal chemistry vol. 46
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Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. [electronic resource] by
- Büttelmann, Bernd
- Peters, Jens-Uwe
- Ceccarelli, Simona
- Kolczewski, Sabine
- Vieira, Eric
- Prinssen, Eric P
- Spooren, Will
- Schuler, Franz
- Huwyler, Jörg
- Porter, Richard H P
- Jaeschke, Georg
Producer: 20060719
In:
Bioorganic & medicinal chemistry letters vol. 16
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3-Amido-3-aryl-piperidines: A Novel Class of Potent, Selective, and Orally Active GlyT1 Inhibitors. [electronic resource] by
- Pinard, Emmanuel
- Alberati, Daniela
- Alvarez-Sanchez, Ruben
- Brom, Virginie
- Burner, Serge
- Fischer, Holger
- Hauser, Nicole
- Kolczewski, Sabine
- Lengyel, Judith
- Mory, Roland
- Saladin, Christian
- Schulz-Gasch, Tanja
- Stalder, Henri
Producer: 20140606
In:
ACS medicinal chemistry letters vol. 5
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Asymmetric synthesis and receptor pharmacology of the group II mGlu receptor ligand (1S,2R,3R,5R,6S)-2-amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid-HYDIA. [electronic resource] by
- Woltering, Thomas J
- Adam, Geo
- Huguenin, Philipp
- Wichmann, Jürgen
- Kolczewski, Sabine
- Gatti, Silvia
- Bourson, Anne
- Kew, James N C
- Richards, Grayson
- Kemp, John A
- Mutel, Vincent
- Knoflach, Frédéric
Producer: 20080723
In:
ChemMedChem vol. 3
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Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. [electronic resource] by
- Jaeschke, Georg
- Porter, Richard
- Büttelmann, Bernd
- Ceccarelli, Simona M
- Guba, Wolfgang
- Kuhn, Bernd
- Kolczewski, Sabine
- Huwyler, Jörg
- Mutel, Vincent
- Peters, Jens-Uwe
- Ballard, Theresa
- Prinssen, Eric
- Vieira, Eric
- Wichmann, Jürgen
- Spooren, Will
Producer: 20070515
In:
Bioorganic & medicinal chemistry letters vol. 17
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Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. [electronic resource] by
- Porter, Richard H P
- Jaeschke, Georg
- Spooren, Will
- Ballard, Theresa M
- Büttelmann, Bernd
- Kolczewski, Sabine
- Peters, Jens-Uwe
- Prinssen, Eric
- Wichmann, Jürgen
- Vieira, Eric
- Mühlemann, Andreas
- Gatti, Silvia
- Mutel, Vincent
- Malherbe, Pari
Producer: 20060112
In:
The Journal of pharmacology and experimental therapeutics vol. 315
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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. [electronic resource] by
- Lindemann, Lothar
- Jaeschke, Georg
- Michalon, Aubin
- Vieira, Eric
- Honer, Michael
- Spooren, Will
- Porter, Richard
- Hartung, Thomas
- Kolczewski, Sabine
- Büttelmann, Bernd
- Flament, Christophe
- Diener, Catherine
- Fischer, Christophe
- Gatti, Silvia
- Prinssen, Eric P
- Parrott, Neil
- Hoffmann, Gerhard
- Wettstein, Joseph G
Producer: 20120116
In:
The Journal of pharmacology and experimental therapeutics vol. 339
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Metabolite identification via LC-SPE-NMR-MS of the in vitro biooxidation products of a lead mGlu5 allosteric antagonist and impact on the improvement of metabolic stability in the series. [electronic resource] by
- Ceccarelli, Simona M
- Schlotterbeck, Götz
- Boissin, Patrick
- Binder, Martin
- Buettelmann, Bernd
- Hanlon, Steven
- Jaeschke, Georg
- Kolczewski, Sabine
- Kupfer, Ernst
- Peters, Jens-Uwe
- Porter, Richard H P
- Prinssen, Eric P
- Rueher, Marianne
- Ruf, Iris
- Spooren, Will
- Stämpfli, Andreas
- Vieira, Eric
Producer: 20080730
In:
ChemMedChem vol. 3
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Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. [electronic resource] by
- Bruni, Giancarlo
- Rennekamp, Andrew J
- Velenich, Andrea
- McCarroll, Matthew
- Gendelev, Leo
- Fertsch, Ethan
- Taylor, Jack
- Lakhani, Parth
- Lensen, Dennis
- Evron, Tama
- Lorello, Paul J
- Huang, Xi-Ping
- Kolczewski, Sabine
- Carey, Galen
- Caldarone, Barbara J
- Prinssen, Eric
- Roth, Bryan L
- Keiser, Michael J
- Peterson, Randall T
- Kokel, David
Producer: 20170515
In:
Nature chemical biology vol. 12
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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey. [electronic resource] by
- Kratochwil, Nicole A
- Gatti-McArthur, Silvia
- Hoener, Marius C
- Lindemann, Lothar
- Christ, Andreas D
- Green, Luke G
- Guba, Wolfgang
- Martin, Rainer E
- Malherbe, Pari
- Porter, Richard H P
- Slack, Jay P
- Winnig, Marcel
- Dehmlow, Henrietta
- Grether, Uwe
- Hertel, Cornelia
- Narquizian, Robert
- Panousis, Constantinos G
- Kolczewski, Sabine
- Steward, Lucinda
Producer: 20120224
In:
Current topics in medicinal chemistry vol. 11
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16.
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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression. [electronic resource] by
- Lindemann, Lothar
- Porter, Richard H
- Scharf, Sebastian H
- Kuennecke, Basil
- Bruns, Andreas
- von Kienlin, Markus
- Harrison, Anthony C
- Paehler, Axel
- Funk, Christoph
- Gloge, Andreas
- Schneider, Manfred
- Parrott, Neil J
- Polonchuk, Liudmila
- Niederhauser, Urs
- Morairty, Stephen R
- Kilduff, Thomas S
- Vieira, Eric
- Kolczewski, Sabine
- Wichmann, Juergen
- Hartung, Thomas
- Honer, Michael
- Borroni, Edilio
- Moreau, Jean-Luc
- Prinssen, Eric
- Spooren, Will
- Wettstein, Joseph G
- Jaeschke, Georg
Producer: 20150509
In:
The Journal of pharmacology and experimental therapeutics vol. 353
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17.
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Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. [electronic resource] by
- Jaeschke, Georg
- Kolczewski, Sabine
- Spooren, Will
- Vieira, Eric
- Bitter-Stoll, Nadia
- Boissin, Patrick
- Borroni, Edilio
- Büttelmann, Bernd
- Ceccarelli, Simona
- Clemann, Nicole
- David, Beatrice
- Funk, Christoph
- Guba, Wolfgang
- Harrison, Anthony
- Hartung, Thomas
- Honer, Michael
- Huwyler, Jörg
- Kuratli, Martin
- Niederhauser, Urs
- Pähler, Axel
- Peters, Jens-Uwe
- Petersen, Ann
- Prinssen, Eric
- Ricci, Antonio
- Rueher, Daniel
- Rueher, Marianne
- Schneider, Manfred
- Spurr, Paul
- Stoll, Theodor
- Tännler, Daniel
- Wichmann, Jürgen
- Porter, Richard H
- Wettstein, Joseph G
- Lindemann, Lothar
Producer: 20150414
In:
Journal of medicinal chemistry vol. 58
Availability: No items available.
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