BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts. [electronic resource]
Producer: 20070925Description: 1763-72 p. digitalISSN:- 0887-6924
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Apoptosis
- Biphenyl Compounds -- pharmacology
- Blotting, Western
- Cell Proliferation
- Cells, Cultured
- Drug Resistance, Neoplasm
- Flow Cytometry
- Humans
- Karyotyping
- Leukemia, Myeloid -- drug therapy
- Middle Aged
- Molecular Mimicry
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- metabolism
- Nitrophenols -- pharmacology
- Peptide Fragments -- chemistry
- Piperazines -- pharmacology
- Proto-Oncogene Proteins -- chemistry
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- STAT5 Transcription Factor -- metabolism
- Signal Transduction
- Sulfonamides -- pharmacology
- Trans-Activators
- bcl-X Protein -- metabolism
- fms-Like Tyrosine Kinase 3 -- antagonists & inhibitors
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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