Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. [electronic resource]
Producer: 20010510Description: 251-4 p. digitalISSN:- 0960-894X
- Animals
- Binding, Competitive
- Combinatorial Chemistry Techniques
- Enzyme Inhibitors -- chemical synthesis
- Inhibitory Concentration 50
- Kinetics
- NADH, NADPH Oxidoreductases -- antagonists & inhibitors
- Polyamines -- chemical synthesis
- Spermidine -- analogs & derivatives
- Spermine -- analogs & derivatives
- Structure-Activity Relationship
- Trypanocidal Agents -- chemical synthesis
- Trypanosoma brucei brucei -- enzymology
- Trypanosoma cruzi -- enzymology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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