Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. [electronic resource]
Producer: 20150117Description: 31043-52 p. digitalISSN:- 1083-351X
- Alzheimer Disease -- genetics
- Amyloid Precursor Protein Secretases -- metabolism
- Amyloid beta-Peptides -- physiology
- Animals
- CHO Cells
- Carboxypeptidases -- metabolism
- Cricetinae
- Cricetulus
- Enzyme-Linked Immunosorbent Assay
- Kinetics
- Mutation
- Peptide Fragments -- physiology
- Presenilin-1 -- genetics
- Protein Structure, Tertiary
- Proteolysis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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