High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer. [electronic resource]
Producer: 20191024Description: 17239 p. digitalISSN:- 2045-2322
- Androgen Receptor Antagonists -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Benzamides -- pharmacology
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Genotype
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- High-Throughput Screening Assays -- methods
- Humans
- Isoindoles -- pharmacology
- Male
- Mice
- PTEN Phosphohydrolase -- metabolism
- Phenotype
- Phosphatidylinositol 3-Kinases -- metabolism
- Prostate -- drug effects
- Prostatic Neoplasms, Castration-Resistant -- drug therapy
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- metabolism
- Triazoles -- pharmacology
- Tumor Suppressor Protein p53 -- metabolism
- Xenograft Model Antitumor Assays -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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