Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma. [electronic resource]
Producer: 20170922Description: 3842-3851 p. digitalISSN:- 1476-5594
- Animals
- Cell Line, Tumor
- Cell Transformation, Neoplastic -- metabolism
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p18 -- metabolism
- Female
- Humans
- Indoles -- pharmacology
- MAP Kinase Kinase 1 -- genetics
- Male
- Melanocytes -- metabolism
- Melanoma, Experimental -- enzymology
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation, Missense
- Neoplasm Transplantation
- PTEN Phosphohydrolase -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- metabolism
- Skin Neoplasms -- enzymology
- Sulfonamides -- pharmacology
- Vemurafenib
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Publication Type: Journal Article
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