Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. [electronic resource]
Producer: 20181127Description: 1157-1170 p. digitalISSN:- 0925-4439
- Alzheimer Disease -- drug therapy
- Animals
- Cerebral Cortex -- metabolism
- Dose-Response Relationship, Drug
- Electron Transport Complex I -- genetics
- Mice
- Mitochondria -- genetics
- Neurons -- metabolism
- Neurotoxicity Syndromes -- drug therapy
- Pyrroles -- pharmacology
- Pyrrolidines -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Ubiquitin Thiolesterase -- antagonists & inhibitors
- Ubiquitination -- drug effects
- tau Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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