Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment. [electronic resource]
Producer: 20200713Description: 485 p. digitalISSN:- 2041-4889
- Animals
- Antineoplastic Agents -- pharmacology
- Caspase 1 -- metabolism
- Cell Line, Tumor
- Colorectal Neoplasms -- drug therapy
- Docosahexaenoic Acids -- pharmacology
- Female
- Fluorouracil -- pharmacology
- Humans
- Inflammasomes -- drug effects
- Interleukin-1beta -- metabolism
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Mice
- Mice, Inbred C57BL
- NLR Family, Pyrin Domain-Containing 3 Protein -- metabolism
- Phosphorylation -- drug effects
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- beta-Arrestin 2 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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