Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. [electronic resource]
Producer: 20100514Description: 3376-88 p. digitalISSN:- 1520-4804
- Administration, Oral
- Aminoquinolines
- Animals
- Anti-HIV Agents -- chemical synthesis
- Benzimidazoles
- Biological Availability
- Butylamines
- Calcium -- metabolism
- Cell Line
- Cell Membrane Permeability
- Dogs
- HIV-1 -- drug effects
- Heterocyclic Compounds, 1-Ring -- chemical synthesis
- Humans
- Leukocytes, Mononuclear -- drug effects
- Radioligand Assay
- Rats
- Receptors, CXCR4 -- antagonists & inhibitors
- Stereoisomerism
- Structure-Activity Relationship
- Virus Replication -- drug effects
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Publication Type: Journal Article
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