Lentiviral-mediated gene therapy results in sustained expression of β-glucuronidase for up to 12 months in the gus(mps/mps) and up to 18 months in the gus(tm(L175F)Sly) mouse models of mucopolysaccharidosis type VII. [electronic resource]
Producer: 20150601Description: 798-810 p. digitalISSN:- 1557-7422
- Analysis of Variance
- Animals
- Bone Density
- Disease Models, Animal
- Exploratory Behavior -- physiology
- Genetic Therapy -- methods
- Genetic Vectors -- genetics
- Glucuronidase -- blood
- Histological Techniques
- Kidney -- metabolism
- Lentivirus
- Liver -- metabolism
- Longevity -- physiology
- Mice
- Mucopolysaccharidosis VII -- enzymology
- Myocardium -- metabolism
- Spatial Learning -- physiology
- Species Specificity
- Spleen -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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