Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists. [electronic resource]
Producer: 20140526Description: 6542-53 p. digitalISSN:- 1464-3391
- Administration, Oral
- Amides -- chemistry
- Analgesics -- chemical synthesis
- Animals
- Disease Models, Animal
- Half-Life
- Male
- Mice
- Mice, Inbred C57BL
- Neuralgia -- drug therapy
- Piperidines -- chemistry
- Protein Binding
- Rats
- Rats, Sprague-Dawley
- Spiro Compounds -- chemistry
- Stereoisomerism
- Structure-Activity Relationship
- TRPM Cation Channels -- antagonists & inhibitors
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Publication Type: Journal Article
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