CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis. [electronic resource]
Producer: 20200515Description: 37 p. digitalISSN:- 1756-8722
- 5'-Nucleotidase -- genetics
- Animals
- Carcinoma, Hepatocellular -- genetics
- Carrier Proteins -- genetics
- Cell Growth Processes -- physiology
- Cell Line, Tumor
- Class II Phosphatidylinositol 3-Kinases -- genetics
- Disease Progression
- Female
- GPI-Linked Proteins -- genetics
- Heterografts
- Humans
- Liver Neoplasms -- genetics
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Middle Aged
- Neoplasm Metastasis
- Phosphatidylinositol 3-Kinases -- metabolism
- Prognosis
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptor, Adenosine A2A -- genetics
- Shelterin Complex
- Signal Transduction
- Telomere-Binding Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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