Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. [electronic resource]
Producer: 20050816Description: 4596-607 p. digitalISSN:- 0022-2623
- Acetonitriles -- chemical synthesis
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Antirheumatic Agents -- chemical synthesis
- Arthritis, Experimental -- drug therapy
- Benzothiazoles
- Humans
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Jurkat Cells
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred DBA
- Rats
- Structure-Activity Relationship
- Thiazoles -- chemical synthesis
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
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Publication Type: Journal Article
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