A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. [electronic resource]
Producer: 20100623Description: 421-31 p. digitalISSN:- 1476-3524
- Alzheimer Disease -- complications
- Amyloid -- metabolism
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Animals, Newborn
- Behavioral Symptoms -- drug therapy
- Brain -- cytology
- Caspases -- metabolism
- Cell Death -- drug effects
- Cell Survival -- drug effects
- Cells, Cultured
- Disease Models, Animal
- Drug Combinations
- Humans
- Maze Learning -- drug effects
- Melatonin -- therapeutic use
- Mice
- Mice, Transgenic
- Mutation -- genetics
- Neurons -- drug effects
- Neuroprotective Agents -- therapeutic use
- Organ Culture Techniques
- Presenilin-1 -- genetics
- Rats
- Tacrine -- therapeutic use
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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