Expression and characterization of a novel human recombinant factor IX molecule with enhanced in vitro and in vivo clotting activity. [electronic resource]
Producer: 20160422Description: 1017-24 p. digitalISSN:- 1879-2472
- Amino Acid Substitution
- Animals
- Blood Coagulation -- drug effects
- Blood Coagulation Tests
- Blood Platelets -- metabolism
- Cell Line
- Disease Models, Animal
- Factor IX -- genetics
- Factor VIIIa -- metabolism
- Factor VIIa -- metabolism
- Factor XIa -- metabolism
- Gene Expression
- Hemophilia B -- blood
- Humans
- In Vitro Techniques
- Male
- Mice
- Mice, Mutant Strains
- Mutagenesis, Site-Directed
- Recombinant Proteins -- genetics
- Thromboplastin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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