Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids. [electronic resource]
Producer: 20131029Description: 1148-52 p. digitalISSN:- 1791-244X
- Cell Death -- drug effects
- Cell Nucleus -- drug effects
- Cell Proliferation -- drug effects
- Chemoprevention
- Collagen Type I -- genetics
- Down-Regulation -- drug effects
- Fibroblasts -- drug effects
- Humans
- Keloid -- drug therapy
- Matrix Metalloproteinases -- metabolism
- Phosphorylation -- drug effects
- Promoter Regions, Genetic -- genetics
- Signal Transduction -- drug effects
- Silybin
- Silymarin -- pharmacology
- Skin -- pathology
- Smad Proteins -- metabolism
- Smad2 Protein -- metabolism
- Smad3 Protein -- metabolism
- Tissue Inhibitor of Metalloproteinase-1 -- metabolism
- Transforming Growth Factor beta1 -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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