SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. [electronic resource]
Producer: 20190704Description: 2532 p. digitalISSN:- 2041-1723
- Animals
- Apoptosis
- Carcinoma, Non-Small-Cell Lung -- genetics
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- Female
- HEK293 Cells
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Lung Neoplasms -- genetics
- MAP Kinase Signaling System
- Male
- Mice, Knockout
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Protein Kinase Inhibitors -- pharmacology
- Protein Multimerization
- raf Kinases -- antagonists & inhibitors
- ras Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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