Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. [electronic resource]
Producer: 20091027Description: 1602-8 p. digitalISSN:- 1468-2060
- Animals
- Arthritis, Experimental -- complications
- Arthritis, Gouty -- complications
- Biomarkers -- metabolism
- Colchicine -- therapeutic use
- Cytokines -- biosynthesis
- Disease Models, Animal
- Drug Evaluation, Preclinical -- methods
- Gout Suppressants -- therapeutic use
- Hyperalgesia -- etiology
- Interleukin-1 -- antagonists & inhibitors
- Male
- Mice
- Mice, Knockout
- Neutrophil Infiltration
- Receptors, Interleukin-1 Type I -- deficiency
- Recombinant Fusion Proteins -- therapeutic use
- Signal Transduction -- physiology
- Synovitis -- etiology
- Up-Regulation -- drug effects
- Uric Acid
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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