Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice. [electronic resource]
Producer: 20210217Description: 2250-2265.e20 p. digitalISSN:- 1528-0012
- Aged
- Aged, 80 and over
- Animals
- Apoptosis
- Carcinoma, Hepatocellular -- immunology
- Cell Proliferation
- Female
- Gene Expression Regulation, Neoplastic
- Glypicans -- genetics
- Granzymes -- metabolism
- Hep G2 Cells
- Humans
- Immunotherapy, Adoptive
- Liver Neoplasms -- immunology
- Male
- Mice, Inbred NOD
- Mice, SCID
- Middle Aged
- Perforin -- metabolism
- Receptors, Chimeric Antigen -- genetics
- T-Lymphocytes -- immunology
- Tumor Burden
- Tumor Microenvironment
- Wnt Signaling Pathway
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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