Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. [electronic resource]
Producer: 20160620Description: 4834-4837 p. digitalISSN:- 1464-3405
- Biological Availability
- Chagas Disease -- drug therapy
- Cysteine Endopeptidases -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Hydrocarbons, Fluorinated -- chemical synthesis
- Ketones -- chemical synthesis
- Molecular Structure
- Protozoan Proteins -- antagonists & inhibitors
- Structure-Activity Relationship
- Trypanocidal Agents -- chemical synthesis
- Trypanosoma cruzi -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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