D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation. [electronic resource]
Producer: 20070316Description: 193-202 p. digitalISSN:- 1535-7163
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Ataxia Telangiectasia Mutated Proteins
- Carcinoma, Renal Cell -- pathology
- Cell Cycle Proteins -- metabolism
- DNA Adducts -- drug effects
- DNA Damage
- DNA-Binding Proteins -- metabolism
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Activation -- drug effects
- Flow Cytometry
- HT29 Cells
- HeLa Cells
- Heterocyclic Compounds, 3-Ring -- pharmacology
- Humans
- Male
- Mice
- Mice, Nude
- Organoselenium Compounds -- pharmacology
- Protein Kinase C -- metabolism
- Protein Kinase C beta
- Protein Kinase C-alpha -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Pyrroles -- pharmacology
- Reactive Oxygen Species -- metabolism
- S Phase -- drug effects
- Signal Transduction -- drug effects
- Tumor Suppressor Proteins -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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