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Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap. [electronic resource] by
- Richards, Duncan
- Bamford, Mark
- Liefaard, Lia
- Haque, Nazneen
- Lewis, Gareth
- Storey, Jim
- Fernando, Disala
- Kumar, Subramanya
- Thompson, Douglas
- Holmes, Duncan S
Producer: 20210621
In:
British journal of pharmacology vol. 177
Availability: No items available.
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3.
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p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression. [electronic resource] by
- Aston, Nicola M
- Bamborough, Paul
- Buckton, Jacqueline B
- Edwards, Christopher D
- Holmes, Duncan S
- Jones, Katherine L
- Patel, Vipulkumar K
- Smee, Penny A
- Somers, Donald O
- Vitulli, Giovanni
- Walker, Ann L
Producer: 20091124
In:
Journal of medicinal chemistry vol. 52
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4.
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Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. [electronic resource] by
- White, Gemma V
- Edgar, Emma V
- Holmes, Duncan S
- Lewell, Xiao Qing
- Liddle, John
- Polyakova, Oxana
- Smith, Kathrine J
- Thorpe, James H
- Walker, Ann L
- Wang, Yichen
- Young, Robert J
- Hovnanian, Alain
Producer: 20200128
In:
Bioorganic & medicinal chemistry letters vol. 29
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5.
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The discovery of quinoline based single-ligand human H [electronic resource] by
- Procopiou, Panayiotis A
- Ancliff, Rachael A
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Keeling, Steven P
- Looker, Brian E
- Parr, Nigel A
- Rowedder, James E
- Slack, Robert J
Producer: 20170627
In:
Bioorganic & medicinal chemistry letters vol. 26
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Design of Phthalazinone Amide Histamine H [electronic resource] by
- Procopiou, Panayiotis A
- Ford, Alison J
- Gore, Paul M
- Looker, Brian E
- Hodgson, Simon T
- Holmes, Duncan S
- Vile, Sadie
- Clark, Kenneth L
- Saunders, Ken A
- Slack, Robert J
- Rowedder, James E
- Watts, Clarissa J
Publication details: ACS medicinal chemistry letters May 2017
In:
ACS medicinal chemistry letters vol. 8
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7.
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H [electronic resource] by
- Procopiou, Panayiotis A
- Ford, Alison J
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Looker, Brian E
- Vile, Sadie
- Clark, Kenneth L
- Saunders, Ken A
- Slack, Robert J
- Watts, Clarissa J
Producer: 20171206
In:
Bioorganic & medicinal chemistry letters vol. 27
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8.
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Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome. [electronic resource] by
- Thorpe, James H
- Edgar, Emma V
- Smith, Kathrine J
- Lewell, Xiao Q
- Rella, Monika
- White, Gemma V
- Polyakova, Oxana
- Nassau, Pamela
- Walker, Ann L
- Holmes, Duncan S
- Pearce, Andrew C
- Wang, Yichen
- Liddle, John
- Hovnanian, Alain
Producer: 20190826
In:
Acta crystallographica. Section F, Structural biology communications vol. 75
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9.
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Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome. [electronic resource] by
- Walker, Ann L
- Bingham, Ryan P
- Edgar, Emma V
- Ferrie, Alan
- Holmes, Duncan S
- Liddle, John
- Polyakova, Oxana
- Rella, Monika
- Smith, Kathrine J
- Thorpe, James H
- Wang, Yichen
- White, Gemma V
- Young, Robert J
- Hovnanian, Alain
Producer: 20200921
In:
Bioorganic & medicinal chemistry letters vol. 29
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10.
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Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing. [electronic resource] by
- Procopiou, Panayiotis A
- Barrett, Victoria J
- Biggadike, Keith
- Butchers, Peter R
- Craven, Andrew
- Ford, Alison J
- Guntrip, Stephen B
- Holmes, Duncan S
- Hughes, Sara C
- Jones, Anne E
- Looker, Brian E
- Mutch, Peter J
- Ruston, Mark
- Needham, Deborah
- Smith, Claire E
Producer: 20140310
In:
Journal of medicinal chemistry vol. 57
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11.
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Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. [electronic resource] by
- Hutchinson, Jonathan P
- Rowland, Paul
- Taylor, Mark R D
- Christodoulou, Erica M
- Haslam, Carl
- Hobbs, Clare I
- Holmes, Duncan S
- Homes, Paul
- Liddle, John
- Mole, Damian J
- Uings, Iain
- Walker, Ann L
- Webster, Scott P
- Mowat, Christopher G
- Chung, Chun-Wa
Producer: 20181121
In:
Nature communications vol. 8
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Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity. [electronic resource] by
- Angell, Richard
- Aston, Nicola M
- Bamborough, Paul
- Buckton, Jacky B
- Cockerill, Stuart
- deBoeck, Suzanne J
- Edwards, Chris D
- Holmes, Duncan S
- Jones, Katherine L
- Laine, Dramane I
- Patel, Shila
- Smee, Penny A
- Smith, Kathryn J
- Somers, Don O
- Walker, Ann L
Producer: 20080822
In:
Bioorganic & medicinal chemistry letters vol. 18
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13.
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In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis. [electronic resource] by
- McBride, Andrew
- Hoy, Anna M
- Bamford, Mark J
- Mossakowska, Danuta E
- Ruediger, Martin P
- Griggs, Jeremy
- Desai, Sapna
- Simpson, Kate
- Caballero-Hernandez, Ivan
- Iredale, John P
- Pell, Theresa
- Aucott, Rebecca L
- Holmes, Duncan S
- Webster, Scott P
- Fallowfield, Jonathan A
Producer: 20190520
In:
Scientific reports vol. 7
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14.
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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors. [electronic resource] by
- Liddle, John
- Bamborough, Paul
- Barker, Michael D
- Campos, Sebastien
- Cousins, Rick P C
- Cutler, Geoffrey J
- Hobbs, Heather
- Holmes, Duncan S
- Ioannou, Chris
- Mellor, Geoff W
- Morse, Mary A
- Payne, Jeremy J
- Pritchard, John M
- Smith, Kathryn J
- Tape, Daniel T
- Whitworth, Caroline
- Williamson, Richard A
Producer: 20090821
In:
Bioorganic & medicinal chemistry letters vol. 19
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15.
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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors. [electronic resource] by
- Walker, Ann L
- Denis, Alexis
- Bingham, Ryan P
- Bouillot, Anne
- Edgar, Emma V
- Ferrie, Alan
- Holmes, Duncan S
- Laroze, Alain
- Liddle, John
- Fouchet, Marie-Helene
- Moquette, Alexandre
- Nassau, Pam
- Pearce, Andrew C
- Polyakova, Oxana
- Smith, Kathrine J
- Thomas, Pamela
- Thorpe, James H
- Trottet, Lionel
- Wang, Yichen
- Hovnanian, Alain
Producer: 20201022
In:
Bioorganic & medicinal chemistry letters vol. 29
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16.
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Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675]. [electronic resource] by
- Walker, Ann L
- Denis, Alexis
- Bingham, Ryan P
- Bouillot, Anne
- Edgar, Emma V
- Ferrie, Alan
- Holmes, Duncan S
- Laroze, Alain
- Liddle, John
- Fouchet, Marie-Helene
- Moquette, Alexandre
- Nassau, Pam
- Pearce, Andrew C
- Polyakova, Oxana
- Smith, Kathrine J
- Thomas, Pamela
- Thorpe, James H
- Trottet, Lionel
- Wang, Yichen
- Hovnanian, Alain
Publication details: Bioorganic & medicinal chemistry letters Jan 2020
In:
Bioorganic & medicinal chemistry letters vol. 30
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17.
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Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation. [electronic resource] by
- Liddle, John
- Hutchinson, Jonathan P
- Kitchen, Semra
- Rowland, Paul
- Neu, Margarete
- Cecconie, Ted
- Holmes, Duncan S
- Jones, Emma
- Korczynska, Justyna
- Koumantou, Despoina
- Lea, Jonathan D
- Nickels, Leng
- Pemberton, Michelle
- Phillipou, Alex
- Schneck, Jessica L
- Sheehan, Hester
- Tinworth, Christopher P
- Uings, Iain
- Wojno-Picon, Justyna
- Young, Robert J
- Stratikos, Efstratios
Producer: 20200914
In:
Journal of medicinal chemistry vol. 63
Availability: No items available.
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18.
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Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. [electronic resource] by
- Walker, Ann L
- Ancellin, Nicolas
- Beaufils, Benjamin
- Bergeal, Marylise
- Binnie, Margaret
- Bouillot, Anne
- Clapham, David
- Denis, Alexis
- Haslam, Carl P
- Holmes, Duncan S
- Hutchinson, Jonathan P
- Liddle, John
- McBride, Andrew
- Mirguet, Olivier
- Mowat, Christopher G
- Rowland, Paul
- Tiberghien, Nathalie
- Trottet, Lionel
- Uings, Iain
- Webster, Scott P
- Zheng, Xiaozhong
- Mole, Damian J
Producer: 20170620
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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19.
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The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. [electronic resource] by
- Liddle, John
- Beaufils, Benjamin
- Binnie, Margaret
- Bouillot, Anne
- Denis, Alexis A
- Hann, Michael M
- Haslam, Carl P
- Holmes, Duncan S
- Hutchinson, Jon P
- Kranz, Michael
- McBride, Andrew
- Mirguet, Olivier
- Mole, Damian J
- Mowat, Christopher G
- Pal, Sandeep
- Rowland, Paul
- Trottet, Lionel
- Uings, Iain J
- Walker, Ann L
- Webster, Scott P
Producer: 20170718
In:
Bioorganic & medicinal chemistry letters vol. 27
Availability: No items available.
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20.
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The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. [electronic resource] by
- Procopiou, Panayiotis A
- Browning, Christopher
- Buckley, Jennifer M
- Clark, Kenneth L
- Fechner, Lise
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Kranz, Michael
- Looker, Brian E
- Morriss, Karen M L
- Parton, Daniel L
- Russell, Linda J
- Slack, Robert J
- Sollis, Steven L
- Vile, Sadie
- Watts, Clarissa J
Producer: 20110606
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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