The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin. [electronic resource]
Producer: 20170620Description: 1458-66 p. digitalISSN:- 1528-1167
- Anticonvulsants -- pharmacology
- Cell Line, Transformed
- Electric Stimulation
- Female
- Green Fluorescent Proteins -- genetics
- Humans
- Isoleucine -- genetics
- Male
- Membrane Potentials -- drug effects
- Models, Molecular
- Mutation -- genetics
- NAV1.6 Voltage-Gated Sodium Channel -- genetics
- Patch-Clamp Techniques
- Phenytoin -- pharmacology
- Sodium Channel Blockers -- pharmacology
- Tetrodotoxin -- pharmacology
- Transfection
- Valine -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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