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Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists. [electronic resource] by
- Ajram, Laura
- Begg, Malcolm
- Slack, Robert
- Cryan, Jenni
- Hall, David
- Hodgson, Simon
- Ford, Alison
- Barnes, Ashley
- Swieboda, Dawid
- Mousnier, Aurelie
- Solari, Roberto
Producer: 20141203
In:
European journal of pharmacology vol. 729
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Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study. [electronic resource] by
- Cahn, Anthony
- Hodgson, Simon
- Wilson, Robert
- Robertson, Jonathan
- Watson, Joanna
- Beerahee, Misba
- Hughes, Steve C
- Young, Graeme
- Graves, Rebecca
- Hall, David
- van Marle, Sjoerd
- Solari, Roberto
Producer: 20150511
In:
BMC pharmacology & toxicology vol. 14
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8.
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Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. [electronic resource] by
- Fryer, Allison D
- Stein, Louis H
- Nie, Zhenying
- Curtis, Damian E
- Evans, Christopher M
- Hodgson, Simon T
- Jose, Peter J
- Belmonte, Kristen E
- Fitch, Erin
- Jacoby, David B
Producer: 20060302
In:
The Journal of clinical investigation vol. 116
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9.
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Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor. [electronic resource] by
- Slack, Robert J
- Russell, Linda J
- Barton, Nick P
- Weston, Cathryn
- Nalesso, Giovanna
- Thompson, Sally-Anne
- Allen, Morven
- Chen, Yu Hua
- Barnes, Ashley
- Hodgson, Simon T
- Hall, David A
Producer: 20141216
In:
Pharmacology research & perspectives vol. 1
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The discovery of quinoline based single-ligand human H [electronic resource] by
- Procopiou, Panayiotis A
- Ancliff, Rachael A
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Keeling, Steven P
- Looker, Brian E
- Parr, Nigel A
- Rowedder, James E
- Slack, Robert J
Producer: 20170627
In:
Bioorganic & medicinal chemistry letters vol. 26
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2,8-Diazaspiro[4.5]decan-8-yl)pyrimidin-4-amine potent CCR4 antagonists capable of inducing receptor endocytosis. [electronic resource] by
- Shukla, Lena
- Ajram, Laura A
- Begg, Malcolm
- Evans, Brian
- Graves, Rebecca H
- Hodgson, Simon T
- Lynn, Sean M
- Miah, Afjal H
- Percy, Jonathan M
- Procopiou, Panayiotis A
- Richards, Stephen A
- Slack, Robert J
Producer: 20161214
In:
European journal of medicinal chemistry vol. 115
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12.
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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H [electronic resource] by
- Procopiou, Panayiotis A
- Ford, Alison J
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Looker, Brian E
- Vile, Sadie
- Clark, Kenneth L
- Saunders, Ken A
- Slack, Robert J
- Watts, Clarissa J
Producer: 20171206
In:
Bioorganic & medicinal chemistry letters vol. 27
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13.
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Design of Phthalazinone Amide Histamine H [electronic resource] by
- Procopiou, Panayiotis A
- Ford, Alison J
- Gore, Paul M
- Looker, Brian E
- Hodgson, Simon T
- Holmes, Duncan S
- Vile, Sadie
- Clark, Kenneth L
- Saunders, Ken A
- Slack, Robert J
- Rowedder, James E
- Watts, Clarissa J
Publication details: ACS medicinal chemistry letters May 2017
In:
ACS medicinal chemistry letters vol. 8
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14.
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Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. [electronic resource] by
- Young, Robert J
- Alderton, Wendy
- Angell, Anthony D R
- Beswick, Paul J
- Brown, David
- Chambers, C Lynn
- Crowe, Miriam C
- Dawson, John
- Hamlett, Christopher C F
- Hodgson, Simon T
- Kleanthous, Savvas
- Knowles, Richard G
- Russell, Linda J
- Stocker, Richard
- Woolven, James M
Producer: 20110823
In:
Bioorganic & medicinal chemistry letters vol. 21
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15.
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The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. [electronic resource] by
- Procopiou, Panayiotis A
- Browning, Christopher
- Buckley, Jennifer M
- Clark, Kenneth L
- Fechner, Lise
- Gore, Paul M
- Hancock, Ashley P
- Hodgson, Simon T
- Holmes, Duncan S
- Kranz, Michael
- Looker, Brian E
- Morriss, Karen M L
- Parton, Daniel L
- Russell, Linda J
- Slack, Robert J
- Sollis, Steven L
- Vile, Sadie
- Watts, Clarissa J
Producer: 20110606
In:
Journal of medicinal chemistry vol. 54
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16.
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4-acyl-1-(4-aminoalkoxyphenyl)-2-ketopiperazines as a novel class of non-brain-penetrant histamine H3 receptor antagonists. [electronic resource] by
- Procopiou, Panayiotis A
- Ancliff, Rachael A
- Bamford, Mark J
- Browning, Christopher
- Connor, Helen
- Davies, Susannah
- Fogden, Yvonne C
- Hodgson, Simon T
- Holmes, Duncan S
- Looker, Brian E
- Morriss, Karen M L
- Parr, Christopher A
- Pickup, Elizabeth A
- Sehmi, Sanjeet S
- White, Gemma V
- Watts, Clarissa J
- Wilson, David M
- Woodrow, Michael D
Producer: 20080403
In:
Journal of medicinal chemistry vol. 50
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17.
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GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. [electronic resource] by
- Heifetz, Alexander
- Schertler, Gebhard F X
- Seifert, Roland
- Tate, Christopher G
- Sexton, Patrick M
- Gurevich, Vsevolod V
- Fourmy, Daniel
- Cherezov, Vadim
- Marshall, Fiona H
- Storer, R Ian
- Moraes, Isabel
- Tikhonova, Irina G
- Tautermann, Christofer S
- Hunt, Peter
- Ceska, Tom
- Hodgson, Simon
- Bodkin, Mike J
- Singh, Shweta
- Law, Richard J
- Biggin, Philip C
Producer: 20160331
In:
Naunyn-Schmiedeberg's archives of pharmacology vol. 388
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18.
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Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151). [electronic resource] by
- Macdonald, Simon J F
- Dowle, Michael D
- Harrison, Lee A
- Clarke, Geoffrey D E
- Inglis, Graham G A
- Johnson, Martin R
- Shah, Pritom
- Smith, Robin A
- Amour, Augustin
- Fleetwood, Gill
- Humphreys, Davina C
- Molloy, Christopher R
- Dixon, Mary
- Godward, Rosalind E
- Wonacott, Alan J
- Singh, Onkar M P
- Hodgson, Simon T
- Hardy, George W
Producer: 20020923
In:
Journal of medicinal chemistry vol. 45
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19.
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Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists. [electronic resource] by
- Procopiou, Panayiotis A
- Barrett, John W
- Barton, Nicholas P
- Begg, Malcolm
- Clapham, David
- Copley, Royston C B
- Ford, Alison J
- Graves, Rebecca H
- Hall, David A
- Hancock, Ashley P
- Hill, Alan P
- Hobbs, Heather
- Hodgson, Simon T
- Jumeaux, Coline
- Lacroix, Yannick M L
- Miah, Afjal H
- Morriss, Karen M L
- Needham, Deborah
- Sheriff, Emma B
- Slack, Robert J
- Smith, Claire E
- Sollis, Steven L
- Staton, Hugo
Producer: 20130514
In:
Journal of medicinal chemistry vol. 56
Availability: No items available.
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20.
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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors. [electronic resource] by
- Deaton, David N
- Do, Young
- Holt, Jason
- Jeune, Michael R
- Kramer, H Fritz
- Larkin, Andrew L
- Orband-Miller, Lisa A
- Peckham, Gregory E
- Poole, Chuck
- Price, Daniel J
- Schaller, Lee T
- Shen, Ying
- Shewchuk, Lisa M
- Stewart, Eugene L
- Stuart, J Darren
- Thomson, Stephen A
- Ward, Paris
- Wilson, Joseph W
- Xu, Tianshun
- Guss, Jeffrey H
- Musetti, Caterina
- Rendina, Alan R
- Affleck, Karen
- Anders, David
- Hancock, Ashley P
- Hobbs, Heather
- Hodgson, Simon T
- Hutchinson, Jonathan
- Leveridge, Melanie V
- Nicholls, Harry
- Smith, Ian E D
- Somers, Don O
- Sneddon, Helen F
- Uddin, Sorif
- Cleasby, Anne
- Mortenson, Paul N
- Richardson, Caroline
- Saxty, Gordon
Producer: 20200217
In:
Bioorganic & medicinal chemistry vol. 27
Availability: No items available.
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