Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. [electronic resource]
Producer: 20200629Description: 369-381 p. digitalISSN:- 1520-4804
- Aldehyde Reductase -- antagonists & inhibitors
- Animals
- Binding Sites
- Drug Design
- Enzyme Assays
- Enzyme Inhibitors -- chemistry
- Female
- Humans
- Indoleacetic Acids -- chemistry
- Indoles -- chemistry
- Lens, Crystalline -- enzymology
- Male
- Molecular Docking Simulation
- Rats, Wistar
- Sulfhydryl Compounds -- chemistry
- Triazines -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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