Celastrus orbiculatus extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in Vitro and in Vivo. [electronic resource]
Producer: 20130627Description: 752-60 p. digitalISSN:- 1993-0402
- Administration, Oral
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma, Hepatocellular -- blood supply
- Celastrus -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Collagen -- metabolism
- Drug Combinations
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- Laminin -- metabolism
- Liver Neoplasms -- blood supply
- Male
- Mice
- Mice, Inbred C57BL
- Neovascularization, Pathologic -- drug therapy
- Neovascularization, Physiologic -- drug effects
- Phytotherapy
- Plant Extracts -- administration & dosage
- Plant Stems -- chemistry
- Proteoglycans -- metabolism
- Signal Transduction -- drug effects
- Transcriptional Activation -- drug effects
- Tumor Burden -- drug effects
- Vascular Endothelial Growth Factor A -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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