JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells. [electronic resource]
Producer: 20200727Description: 113728 p. digitalISSN:- 1873-2968
- Anthracenes -- pharmacology
- Antineoplastic Agents -- pharmacology
- Carcinoma, Hepatocellular -- metabolism
- Cell Death -- drug effects
- Cell Line, Tumor
- Enzyme Activation -- drug effects
- Hep G2 Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Liver Neoplasms -- metabolism
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Oxidative Stress -- drug effects
- Protein Transport -- drug effects
- Reactive Oxygen Species -- metabolism
- Sorafenib -- pharmacology
- Voltage-Dependent Anion Channels -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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