AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway. [electronic resource]
Producer: 20050526Description: 572-9 p. digitalISSN:- 0887-6924
- Animals
- Apoptosis -- drug effects
- Caspase 3
- Caspase 9
- Caspases -- metabolism
- Cell Survival -- drug effects
- Cytochromes c -- metabolism
- Depsipeptides -- pharmacology
- Humans
- In Vitro Techniques
- Leukemia, B-Cell -- drug therapy
- Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy
- Luciferases -- genetics
- Membrane Potentials -- drug effects
- Mice
- Mice, Transgenic
- Mitochondria -- physiology
- NF-kappa B -- genetics
- Peptides, Cyclic -- pharmacology
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Serratia marcescens -- chemistry
- Transfection
- bcl-2-Associated X Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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