Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity. [electronic resource]
Producer: 20160808Description: 14533 p. digitalISSN:- 2045-2322
- Adenosine Diphosphate -- metabolism
- Adenosine Triphosphate -- antagonists & inhibitors
- Amidines -- chemical synthesis
- Animals
- Anti-Obesity Agents -- chemical synthesis
- Cannabinoid Receptor Antagonists -- chemical synthesis
- Cell Line
- Dogs
- Dose-Response Relationship, Drug
- Drug Design
- Electron Transport Chain Complex Proteins -- antagonists & inhibitors
- Humans
- Mice
- Mitochondria -- drug effects
- Mitochondrial ADP, ATP Translocases -- antagonists & inhibitors
- Muscle, Skeletal -- drug effects
- Myoblasts -- cytology
- Obesity -- drug therapy
- Oxygen Consumption -- drug effects
- Pyrazoles -- chemical synthesis
- Reactive Oxygen Species -- agonists
- Receptor, Cannabinoid, CB1 -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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