The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y [electronic resource]
Producer: 20191107Description: 2501-2514 p. digitalISSN:- 1538-7836
- Adult
- Animals
- Blood Platelets -- drug effects
- COS Cells
- Chlorocebus aethiops
- Drug Interactions
- Female
- HEK293 Cells
- Humans
- Male
- Middle Aged
- Pharmacogenomic Variants
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- pharmacology
- Polymorphism, Single Nucleotide
- Purinergic P2Y Receptor Antagonists -- pharmacology
- Receptors, Purinergic P2Y12 -- drug effects
- Receptors, Thrombin -- agonists
- Risk Factors
- Stroke -- blood
- Thrombin -- pharmacology
- Ticagrelor -- pharmacology
- Young Adult
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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