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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats. [electronic resource] by
- Brotschi, Christine
- Roch, Catherine
- Gatfield, John
- Treiber, Alexander
- Williams, Jodi T
- Sifferlen, Thierry
- Heidmann, Bibia
- Jenck, Francois
- Bolli, Martin H
- Boss, Christoph
Producer: 20200406
In:
ChemMedChem vol. 14
Availability: No items available.
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2.
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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs. [electronic resource] by
- Brotschi, Christine
- Bolli, Martin H
- Gatfield, John
- Heidmann, Bibia
- Jenck, Francois
- Roch, Catherine
- Sifferlen, Thierry
- Treiber, Alexander
- Williams, Jodi T
- Boss, Christoph
Producer: 20210407
In:
ChemMedChem vol. 15
Availability: No items available.
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3.
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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach. [electronic resource] by
- Heidmann, Bibia
- Gatfield, John
- Roch, Catherine
- Treiber, Alexander
- Tortoioli, Simone
- Brotschi, Christine
- Williams, Jodi T
- Bolli, Martin H
- Abele, Stefan
- Sifferlen, Thierry
- Jenck, François
- Boss, Christoph
Producer: 20170630
In:
ChemMedChem vol. 11
Availability: No items available.
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4.
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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2. [electronic resource] by
- Sifferlen, Thierry
- Boller, Amandine
- Chardonneau, Audrey
- Cottreel, Emmanuelle
- Gatfield, John
- Treiber, Alexander
- Roch, Catherine
- Jenck, Francois
- Aissaoui, Hamed
- Williams, Jodi T
- Brotschi, Christine
- Heidmann, Bibia
- Siegrist, Romain
- Boss, Christoph
Producer: 20160219
In:
Bioorganic & medicinal chemistry letters vol. 25
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5.
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Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. [electronic resource] by
- Boss, Christoph
- Roch-Brisbare, Catherine
- Steiner, Michel A
- Treiber, Alexander
- Dietrich, Hendrik
- Jenck, Francois
- von Raumer, Markus
- Sifferlen, Thierry
- Brotschi, Christine
- Heidmann, Bibia
- Williams, Jodi T
- Aissaoui, Hamed
- Siegrist, Romain
- Gatfield, John
Producer: 20150623
In:
ChemMedChem vol. 9
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6.
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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1. [electronic resource] by
- Sifferlen, Thierry
- Boller, Amandine
- Chardonneau, Audrey
- Cottreel, Emmanuelle
- Hoecker, Johannes
- Aissaoui, Hamed
- Williams, Jodi T
- Brotschi, Christine
- Heidmann, Bibia
- Siegrist, Romain
- Gatfield, John
- Treiber, Alexander
- Brisbare-Roch, Catherine
- Jenck, Francois
- Boss, Christoph
Producer: 20141008
In:
Bioorganic & medicinal chemistry letters vol. 24
Availability: No items available.
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7.
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Identification of a new chemical class of antimalarials. [electronic resource] by
- Brunner, Ralf
- Aissaoui, Hamed
- Boss, Christoph
- Bozdech, Zbynek
- Brun, Reto
- Corminboeuf, Olivier
- Delahaye, Stephane
- Fischli, Christoph
- Heidmann, Bibia
- Kaiser, Marcel
- Kamber, Jolanda
- Meyer, Solange
- Papastogiannidis, Petros
- Siegrist, Romain
- Voss, Till
- Welford, Richard
- Wittlin, Sergio
- Binkert, Christoph
Producer: 20130108
In:
The Journal of infectious diseases vol. 206
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8.
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Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. [electronic resource] by
- Bezençon, Olivier
- Heidmann, Bibia
- Siegrist, Romain
- Stamm, Simon
- Richard, Sylvia
- Pozzi, Davide
- Corminboeuf, Olivier
- Roch, Catherine
- Kessler, Melanie
- Ertel, Eric A
- Reymond, Isabelle
- Pfeifer, Thomas
- de Kanter, Ruben
- Toeroek-Schafroth, Michael
- Moccia, Luca G
- Mawet, Jacques
- Moon, Richard
- Rey, Markus
- Capeleto, Bruno
- Fournier, Elvire
Producer: 20171229
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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9.
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Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies. [electronic resource] by
- Bezençon, Olivier
- Siegrist, Romain
- Heidmann, Bibia
- Pozzi, Davide
- Stamm, Simon
- Remeň, Luboš
- Richard, Sylvia
- Simons, Lloyd
- Gaston, Rick
- Downing, Dennis
- Grisostomi, Corinna
- Roch, Catherine
- Kessler, Melanie
- Gatfield, John
- Moon, Richard
- Pfeifer, Thomas
- Mosbacher, Johannes
- Reymond, Isabelle
- Ertel, Eric A
- de Kanter, Ruben
- Capeleto, Bruno
- Fournier, Elvire
- Rey, Markus
- Moccia, Luca
- Toeroek-Schafroth, Michael
- Roscher, René
- Schindelholz, Benno
Producer: 20180206
In:
Chimia vol. 71
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10.
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UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. [electronic resource] by
- Brunner, Ralf
- Ng, Caroline L
- Aissaoui, Hamed
- Akabas, Myles H
- Boss, Christoph
- Brun, Reto
- Callaghan, Paul S
- Corminboeuf, Olivier
- Fidock, David A
- Frame, Ithiel J
- Heidmann, Bibia
- Le Bihan, Amélie
- Jenö, Paul
- Mattheis, Corinna
- Moes, Suzette
- Müller, Ingrid B
- Paguio, Michelle
- Roepe, Paul D
- Siegrist, Romain
- Voss, Till
- Welford, Richard W D
- Wittlin, Sergio
- Binkert, Christoph
Producer: 20131021
In:
The Journal of biological chemistry vol. 288
Availability: No items available.
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11.
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Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action. [electronic resource] by
- Boss, Christoph
- Aissaoui, Hamed
- Amaral, Nathalie
- Bauer, Aude
- Bazire, Stephanie
- Binkert, Christoph
- Brun, Reto
- Bürki, Cédric
- Ciana, Claire-Lise
- Corminboeuf, Olivier
- Delahaye, Stephane
- Dollinger, Claire
- Fischli, Christoph
- Fischli, Walter
- Flock, Alexandre
- Frantz, Marie-Céline
- Girault, Malory
- Grisostomi, Corinna
- Friedli, Astrid
- Heidmann, Bibia
- Hinder, Claire
- Jacob, Gael
- Le Bihan, Amelie
- Malrieu, Sophie
- Mamzed, Saskia
- Merot, Aurelien
- Meyer, Solange
- Peixoto, Sabrina
- Petit, Nolwenn
- Siegrist, Romain
- Trollux, Julien
- Weller, Thomas
- Wittlin, Sergio
Producer: 20170613
In:
ChemMedChem vol. 11
Availability: No items available.
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12.
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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. [electronic resource] by
- Le Bihan, Amélie
- de Kanter, Ruben
- Angulo-Barturen, Iñigo
- Binkert, Christoph
- Boss, Christoph
- Brun, Reto
- Brunner, Ralf
- Buchmann, Stephan
- Burrows, Jeremy
- Dechering, Koen J
- Delves, Michael
- Ewerling, Sonja
- Ferrer, Santiago
- Fischli, Christoph
- Gamo-Benito, Francisco Javier
- Gnädig, Nina F
- Heidmann, Bibia
- Jiménez-Díaz, María Belén
- Leroy, Didier
- Martínez, Maria Santos
- Meyer, Solange
- Moehrle, Joerg J
- Ng, Caroline L
- Noviyanti, Rintis
- Ruecker, Andrea
- Sanz, Laura María
- Sauerwein, Robert W
- Scheurer, Christian
- Schleiferboeck, Sarah
- Sinden, Robert
- Snyder, Christopher
- Straimer, Judith
- Wirjanata, Grennady
- Marfurt, Jutta
- Price, Ric N
- Weller, Thomas
- Fischli, Walter
- Fidock, David A
- Clozel, Martine
- Wittlin, Sergio
Producer: 20170529
In:
PLoS medicine vol. 13
Availability: No items available.
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