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Noncovalent wild-type-sparing inhibitors of EGFR T790M. [electronic resource] by
- Lee, Ho-June
- Schaefer, Gabriele
- Heffron, Timothy P
- Shao, Lily
- Ye, Xiaofen
- Sideris, Steve
- Malek, Shiva
- Chan, Emily
- Merchant, Mark
- La, Hank
- Ubhayakar, Savita
- Yauch, Robert L
- Pirazzoli, Valentina
- Politi, Katerina
- Settleman, Jeff
Producer: 20130820
In:
Cancer discovery vol. 3
Availability: No items available.
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10.
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Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. [electronic resource] by
- Smelick, Gillian S
- Heffron, Timothy P
- Chu, Laura
- Dean, Brian
- West, David A
- Duvall, Scott L
- Lum, Bert L
- Budha, Nageshwar
- Holden, Scott N
- Benet, Leslie Z
- Frymoyer, Adam
- Dresser, Mark J
- Ware, Joseph A
Producer: 20141029
In:
Molecular pharmaceutics vol. 10
Availability: No items available.
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11.
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Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947. [electronic resource] by
- Liu, Xingrong
- Liang, Xiaorong
- LeCouter, Jenninfer
- Ubhayakar, Savita
- Chen, Jacob
- Cheng, Jay
- Lee, Tom
- Lubach, Joe
- Nonomiya, Jim
- Shahidi-Latham, Sheerin
- Quiason, Cristine
- Solon, Eric
- Wright, Matthew
- Hop, Cornelis E C A
- Heffron, Timothy P
Producer: 20210719
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 48
Availability: No items available.
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12.
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4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase. [electronic resource] by
- Hanan, Emily J
- Baumgardner, Matt
- Bryan, Marian C
- Chen, Yuan
- Eigenbrot, Charles
- Fan, Peter
- Gu, Xiao-Hui
- La, Hank
- Malek, Shiva
- Purkey, Hans E
- Schaefer, Gabriele
- Schmidt, Stephen
- Sideris, Steve
- Yen, Ivana
- Yu, Christine
- Heffron, Timothy P
Producer: 20170116
In:
Bioorganic & medicinal chemistry letters vol. 26
Availability: No items available.
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13.
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Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer. [electronic resource] by
- Wu, Ping
- Sneeringer, Christopher J
- Pitts, Keith E
- Day, Eric S
- Chan, Bryan K
- Wei, Binqing
- Lehoux, Isabelle
- Mortara, Kyle
- Li, Hong
- Wu, Jiansheng
- Franke, Yvonne
- Moffat, John G
- Grogan, Jane L
- Heffron, Timothy P
- Wang, Weiru
Producer: 20200221
In:
Structure (London, England : 1993) vol. 27
Availability: No items available.
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14.
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Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase. [electronic resource] by
- Staben, Steven T
- Blaquiere, Nicole
- Tsui, Vickie
- Kolesnikov, Aleksandr
- Do, Steven
- Bradley, Erin K
- Dotson, Jenna
- Goldsmith, Richard
- Heffron, Timothy P
- Lesnick, John
- Lewis, Cristina
- Murray, Jeremy
- Nonomiya, Jim
- Olivero, Alan G
- Pang, Jodie
- Rouge, Lionel
- Salphati, Laurent
- Wei, BinQing
- Wiesmann, Christian
- Wu, Ping
Producer: 20130625
In:
Bioorganic & medicinal chemistry letters vol. 23
Availability: No items available.
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15.
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Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR. [electronic resource] by
- Heffron, Timothy P
- Ndubaku, Chudi O
- Salphati, Laurent
- Alicke, Bruno
- Cheong, Jonathan
- Drobnick, Joy
- Edgar, Kyle
- Gould, Stephen E
- Lee, Leslie B
- Lesnick, John D
- Lewis, Cristina
- Nonomiya, Jim
- Pang, Jodie
- Plise, Emile G
- Sideris, Steve
- Wallin, Jeffrey
- Wang, Lan
- Zhang, Xiaolin
- Olivero, Alan G
Producer: 20160420
In:
ACS medicinal chemistry letters vol. 7
Availability: No items available.
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16.
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The design and identification of brain penetrant inhibitors of phosphoinositide 3-kinase α. [electronic resource] by
- Heffron, Timothy P
- Salphati, Laurent
- Alicke, Bruno
- Cheong, Jonathan
- Dotson, Jennafer
- Edgar, Kyle
- Goldsmith, Richard
- Gould, Stephen E
- Lee, Leslie B
- Lesnick, John D
- Lewis, Cristina
- Ndubaku, Chudi
- Nonomiya, Jim
- Olivero, Alan G
- Pang, Jodie
- Plise, Emile G
- Sideris, Steve
- Trapp, Sean
- Wallin, Jeffrey
- Wang, Lan
- Zhang, Xiaolin
Producer: 20121204
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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17.
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Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform. [electronic resource] by
- Heffron, Timothy P
- Wei, Binqing
- Olivero, Alan
- Staben, Steven T
- Tsui, Vickie
- Do, Steven
- Dotson, Jennafer
- Folkes, Adrian J
- Goldsmith, Paul
- Goldsmith, Richard
- Gunzner, Janet
- Lesnick, John
- Lewis, Cristina
- Mathieu, Simon
- Nonomiya, Jim
- Shuttleworth, Stephen
- Sutherlin, Daniel P
- Wan, Nan Chi
- Wang, Shumei
- Wiesmann, Christian
- Zhu, Bing-Yan
Producer: 20120207
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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18.
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Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma. [electronic resource] by
- Salphati, Laurent
- Alicke, Bruno
- Heffron, Timothy P
- Shahidi-Latham, Sheerin
- Nishimura, Merry
- Cao, Tim
- Carano, Richard A
- Cheong, Jonathan
- Greve, Joan
- Koeppen, Hartmut
- Lau, Shari
- Lee, Leslie B
- Nannini-Pepe, Michelle
- Pang, Jodie
- Plise, Emile G
- Quiason, Cristine
- Rangell, Linda
- Zhang, Xiaolin
- Gould, Stephen E
- Phillips, Heidi S
- Olivero, Alan G
Producer: 20180111
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 44
Availability: No items available.
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19.
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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. [electronic resource] by
- Heffron, Timothy P
- Berry, Megan
- Castanedo, Georgette
- Chang, Christine
- Chuckowree, Irina
- Dotson, Jennafer
- Folkes, Adrian
- Gunzner, Janet
- Lesnick, John D
- Lewis, Cristina
- Mathieu, Simon
- Nonomiya, Jim
- Olivero, Alan
- Pang, Jodie
- Peterson, David
- Salphati, Laurent
- Sampath, Deepak
- Sideris, Steve
- Sutherlin, Daniel P
- Tsui, Vickie
- Wan, Nan Chi
- Wang, Shumei
- Wong, Susan
- Zhu, Bing-Yan
Producer: 20100812
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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20.
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Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR. [electronic resource] by
- Bryan, Marian C
- Burdick, Daniel J
- Chan, Bryan K
- Chen, Yuan
- Clausen, Saundra
- Dotson, Jennafer
- Eigenbrot, Charles
- Elliott, Richard
- Hanan, Emily J
- Heald, Robert
- Jackson, Philip
- La, Hank
- Lainchbury, Michael
- Malek, Shiva
- Mann, Sam E
- Purkey, Hans E
- Schaefer, Gabriele
- Schmidt, Stephen
- Seward, Eileen
- Sideris, Steve
- Wang, Shumei
- Yen, Ivana
- Yu, Christine
- Heffron, Timothy P
Producer: 20160128
In:
ACS medicinal chemistry letters vol. 7
Availability: No items available.
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