Results
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Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors. [electronic resource] by
- Seefeld, Mark A
- Rouse, Meagan B
- McNulty, Kenneth C
- Sun, Lihui
- Wang, Jizhou
- Yamashita, Dennis S
- Luengo, Juan I
- Zhang, Shuyun
- Minthorn, Elisabeth A
- Concha, Nestor O
- Heerding, Dirk A
Producer: 20090826
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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5.
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Aminofurazans as potent inhibitors of AKT kinase. [electronic resource] by
- Rouse, Meagan B
- Seefeld, Mark A
- Leber, Jack D
- McNulty, Kenneth C
- Sun, Lihui
- Miller, William H
- Zhang, Shuyun
- Minthorn, Elisabeth A
- Concha, Nestor O
- Choudhry, Anthony E
- Schaber, Michael D
- Heerding, Dirk A
Producer: 20090828
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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6.
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Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. [electronic resource] by
- Dumble, Melissa
- Crouthamel, Ming-Chih
- Zhang, Shu-Yun
- Schaber, Michael
- Levy, Dana
- Robell, Kimberly
- Liu, Qi
- Figueroa, David J
- Minthorn, Elisabeth A
- Seefeld, Mark A
- Rouse, Meagan B
- Rabindran, Sridhar K
- Heerding, Dirk A
- Kumar, Rakesh
Producer: 20150219
In:
PloS one vol. 9
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7.
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2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. [electronic resource] by
- Lin, Hong
- Yamashita, Dennis S
- Zeng, Jin
- Xie, Ren
- Verma, Sharad
- Luengo, Juan I
- Rhodes, Nelson
- Zhang, Shuyun
- Robell, Kimberly A
- Choudhry, Anthony E
- Lai, Zhihong
- Kumar, Rakesh
- Minthorn, Elisabeth A
- Brown, Kristin K
- Heerding, Dirk A
Producer: 20100420
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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8.
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Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. [electronic resource] by
- Axten, Jeffrey M
- Romeril, Stuart P
- Shu, Arthur
- Ralph, Jeffrey
- Medina, Jesús R
- Feng, Yanhong
- Li, William Hoi Hong
- Grant, Seth W
- Heerding, Dirk A
- Minthorn, Elisabeth
- Mencken, Thomas
- Gaul, Nathan
- Goetz, Aaron
- Stanley, Thomas
- Hassell, Annie M
- Gampe, Robert T
- Atkins, Charity
- Kumar, Rakesh
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 4
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9.
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2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity. [electronic resource] by
- Lin, Hong
- Yamashita, Dennis S
- Zeng, Jin
- Xie, Ren
- Wang, Wenyong
- Nidarmarthy, Sirishkumar
- Luengo, Juan I
- Rhodes, Nelson
- Knick, Victoria B
- Choudhry, Anthony E
- Lai, Zhihong
- Minthorn, Elisabeth A
- Strum, Susan L
- Wood, Edgar R
- Elkins, Patricia A
- Concha, Nestor O
- Heerding, Dirk A
Producer: 20100420
In:
Bioorganic & medicinal chemistry letters vol. 20
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10.
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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity. [electronic resource] by
- Concha, Nestor O
- Smallwood, Angela
- Bonnette, William
- Totoritis, Rachel
- Zhang, Guofeng
- Federowicz, Kelly
- Yang, Jingsong
- Qi, Hongwei
- Chen, Stephanie
- Campobasso, Nino
- Choudhry, Anthony E
- Shuster, Leanna E
- Evans, Karen A
- Ralph, Jeff
- Sweitzer, Sharon
- Heerding, Dirk A
- Buser, Carolyn A
- Su, Dai-Shi
- DeYoung, M Phillip
Producer: 20160212
In:
Molecular pharmacology vol. 88
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11.
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Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). [electronic resource] by
- Miller, William H
- Seefeld, Mark A
- Newlander, Kenneth A
- Uzinskas, Irene N
- Burgess, Walter J
- Heerding, Dirk A
- Yuan, Catherine C K
- Head, Martha S
- Payne, David J
- Rittenhouse, Stephen F
- Moore, Terrance D
- Pearson, Stewart C
- Berry, Valerie
- DeWolf, Walter E
- Keller, Paul M
- Polizzi, Brian J
- Qiu, Xiayang
- Janson, Cheryl A
- Huffman, William F
Producer: 20020812
In:
Journal of medicinal chemistry vol. 45
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12.
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Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. [electronic resource] by
- Su, Dai-Shi
- Qu, Junya
- Schulz, Mark
- Blackledge, Chuck W
- Yu, Hongyi
- Zeng, Jenny
- Burgess, Joelle
- Reif, Alexander
- Stern, Melissa
- Nagarajan, Raman
- Pappalardi, Melissa Baker
- Wong, Kristen
- Graves, Alan P
- Bonnette, William
- Wang, Liping
- Elkins, Patricia
- Knapp-Reed, Beth
- Carson, Jeffrey D
- McHugh, Charles
- Mohammad, Helai
- Kruger, Ryan
- Luengo, Juan
- Heerding, Dirk A
- Creasy, Caretha L
Publication details: ACS medicinal chemistry letters Feb 2020
In:
ACS medicinal chemistry letters vol. 11
Availability: No items available.
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13.
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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). [electronic resource] by
- Axten, Jeffrey M
- Medina, Jesús R
- Feng, Yanhong
- Shu, Arthur
- Romeril, Stuart P
- Grant, Seth W
- Li, William Hoi Hong
- Heerding, Dirk A
- Minthorn, Elisabeth
- Mencken, Thomas
- Atkins, Charity
- Liu, Qi
- Rabindran, Sridhar
- Kumar, Rakesh
- Hong, Xuan
- Goetz, Aaron
- Stanley, Thomas
- Taylor, J David
- Sigethy, Scott D
- Tomberlin, Ginger H
- Hassell, Annie M
- Kahler, Kirsten M
- Shewchuk, Lisa M
- Gampe, Robert T
Producer: 20121126
In:
Journal of medicinal chemistry vol. 55
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14.
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Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. [electronic resource] by
- Rhodes, Nelson
- Heerding, Dirk A
- Duckett, Derek R
- Eberwein, Derek J
- Knick, Victoria B
- Lansing, Timothy J
- McConnell, Randy T
- Gilmer, Tona M
- Zhang, Shu-Yun
- Robell, Kimberly
- Kahana, Jason A
- Geske, Robert S
- Kleymenova, Elena V
- Choudhry, Anthony E
- Lai, Zhihong
- Leber, Jack D
- Minthorn, Elisabeth A
- Strum, Susan L
- Wood, Edgar R
- Huang, Pearl S
- Copeland, Robert A
- Kumar, Rakesh
Producer: 20080425
In:
Cancer research vol. 68
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15.
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Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines. [electronic resource] by
- Lin, Hong
- Yamashita, Dennis S
- Xie, Ren
- Zeng, Jin
- Wang, Wenyong
- Leber, Jack
- Safonov, Igor G
- Verma, Sharad
- Li, Mei
- Lafrance, Louis
- Venslavsky, Joseph
- Takata, Dennis
- Luengo, Juan I
- Kahana, Jason A
- Zhang, Shuyun
- Robell, Kimberly A
- Levy, Dana
- Kumar, Rakesh
- Choudhry, Anthony E
- Schaber, Michael
- Lai, Zhihong
- Brown, Barry S
- Donovan, Brian T
- Minthorn, Elisabeth A
- Brown, Kristin K
- Heerding, Dirk A
Producer: 20100420
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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16.
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Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. [electronic resource] by
- Gilmartin, Aidan G
- Faitg, Thomas H
- Richter, Mark
- Groy, Arthur
- Seefeld, Mark A
- Darcy, Michael G
- Peng, Xin
- Federowicz, Kelly
- Yang, Jingsong
- Zhang, Shu-Yun
- Minthorn, Elisabeth
- Jaworski, Jon-Paul
- Schaber, Michael
- Martens, Stan
- McNulty, Dean E
- Sinnamon, Robert H
- Zhang, Hong
- Kirkpatrick, Robert B
- Nevins, Neysa
- Cui, Guanglei
- Pietrak, Beth
- Diaz, Elsie
- Jones, Amber
- Brandt, Martin
- Schwartz, Benjamin
- Heerding, Dirk A
- Kumar, Rakesh
Producer: 20140408
In:
Nature chemical biology vol. 10
Availability: No items available.
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17.
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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin alphavbeta3) antagonists. [electronic resource] by
- Miller, William H
- Manley, Peter J
- Cousins, Russell D
- Erhard, Karl F
- Heerding, Dirk A
- Kwon, Chet
- Ross, Stephen T
- Samanen, James M
- Takata, Dennis T
- Uzinskas, Irene N
- Yuan, Catherine C K
- Haltiwanger, R Curtis
- Gress, Catherine J
- Lark, Michael W
- Hwang, Shing Mei
- James, Ian E
- Rieman, David J
- Willette, Robert N
- Yue, Tian Li
- Azzarano, Leonard M
- Salyers, Kevin L
- Smith, Brian R
- Ward, Keith W
- Johanson, Kyung O
- Huffman, William F
Producer: 20031205
In:
Bioorganic & medicinal chemistry letters vol. 13
Availability: No items available.
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18.
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Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. [electronic resource] by
- Heerding, Dirk A
- Rhodes, Nelson
- Leber, Jack D
- Clark, Tammy J
- Keenan, Richard M
- Lafrance, Louis V
- Li, Mei
- Safonov, Igor G
- Takata, Dennis T
- Venslavsky, Joseph W
- Yamashita, Dennis S
- Choudhry, Anthony E
- Copeland, Robert A
- Lai, Zhihong
- Schaber, Michael D
- Tummino, Peter J
- Strum, Susan L
- Wood, Edgar R
- Duckett, Derek R
- Eberwein, Derek
- Knick, Victoria B
- Lansing, Timothy J
- McConnell, Randy T
- Zhang, Shuyun
- Minthorn, Elisabeth A
- Concha, Nestor O
- Warren, Gregory L
- Kumar, Rakesh
Producer: 20081009
In:
Journal of medicinal chemistry vol. 51
Availability: No items available.
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19.
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Discovery of a novel and potent class of FabI-directed antibacterial agents. [electronic resource] by
- Payne, David J
- Miller, William H
- Berry, Valerie
- Brosky, John
- Burgess, Walter J
- Chen, Emile
- DeWolf, Walter E
- Fosberry, Andrew P
- Greenwood, Rebecca
- Head, Martha S
- Heerding, Dirk A
- Janson, Cheryl A
- Jaworski, Deborah D
- Keller, Paul M
- Manley, Peter J
- Moore, Terrance D
- Newlander, Kenneth A
- Pearson, Stewart
- Polizzi, Brian J
- Qiu, Xiayang
- Rittenhouse, Stephen F
- Slater-Radosti, Courtney
- Salyers, Kevin L
- Seefeld, Mark A
- Smyth, Martin G
- Takata, Dennis T
- Uzinskas, Irene N
- Vaidya, Kalindi
- Wallis, Nicola G
- Winram, Scott B
- Yuan, Catherine C K
- Huffman, William F
Producer: 20030225
In:
Antimicrobial agents and chemotherapy vol. 46
Availability: No items available.
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