Synthesis of Apoptotic New Quinazolinone-Based Compound and Identification of its Underlying Mitochondrial Signalling Pathway in Breast Cancer Cells. [electronic resource]
Producer: 20160503Description: 3417-26 p. digitalISSN:- 1873-4286
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Caspases -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Proliferation -- drug effects
- Cytochromes c -- metabolism
- Dose-Response Relationship, Drug
- Drug Design
- Female
- Humans
- Inhibitory Concentration 50
- L-Lactate Dehydrogenase -- metabolism
- MCF-7 Cells
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Molecular Structure
- NF-kappa B -- metabolism
- Quinazolinones -- chemical synthesis
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Structure-Activity Relationship
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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