Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. [electronic resource]
Producer: 19980730Description: 2213-21 p. digitalISSN:- 0950-1991
- Animals
- Blood Glucose -- analysis
- Cell Differentiation
- Cell Lineage
- DNA-Binding Proteins -- genetics
- Diabetes Mellitus -- etiology
- Eye Proteins
- Gene Targeting
- Genes, Homeobox
- Glucagon -- biosynthesis
- Homeobox Protein Nkx-2.2
- Homeodomain Proteins -- genetics
- Immunohistochemistry
- Insulin -- biosynthesis
- Islets of Langerhans -- cytology
- Mice
- Mutation
- PAX6 Transcription Factor
- Paired Box Transcription Factors
- Pancreatic Polypeptide -- biosynthesis
- Repressor Proteins
- Somatostatin -- biosynthesis
- Transcription Factors -- genetics
- Zebrafish Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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