Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases. [electronic resource]
Producer: 20050103Description: 5894-911 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Cell Line, Tumor
- Cells, Cultured
- Crystallography, X-Ray
- Cyclin D1 -- antagonists & inhibitors
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinases -- antagonists & inhibitors
- Drug Screening Assays, Antitumor
- Humans
- Mice
- Models, Molecular
- Molecular Structure
- Phosphorylation
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Pyrazoles -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Structure-Activity Relationship
- Transplantation, Heterologous
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Publication Type: Journal Article
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