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Targeting IRAK4 for Degradation with PROTACs. [electronic resource] by
- Nunes, Joao
- McGonagle, Grant A
- Eden, Jessica
- Kiritharan, Girieshanie
- Touzet, Megane
- Lewell, Xiao
- Emery, John
- Eidam, Hilary
- Harling, John D
- Anderson, Niall A
Publication details: ACS medicinal chemistry letters Jul 2019
In:
ACS medicinal chemistry letters vol. 10
Availability: No items available.
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PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. [electronic resource] by
- Tinworth, Christopher P
- Lithgow, Hannah
- Dittus, Lars
- Bassi, Zuni I
- Hughes, Sophie E
- Muelbaier, Marcel
- Dai, Han
- Smith, Ian E D
- Kerr, William J
- Burley, Glenn A
- Bantscheff, Marcus
- Harling, John D
Producer: 20191218
In:
ACS chemical biology vol. 14
Availability: No items available.
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11.
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The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents. [electronic resource] by
- Austin, Nigel E
- Hadley, Michael S
- Harling, John D
- Harrington, Frank P
- Macdonald, Gregor J
- Mitchell, Darren J
- Riley, Graham J
- Stean, Tania O
- Stemp, Geoffrey
- Stratton, Sharon C
- Thompson, Mervyn
- Upton, Neil
Producer: 20040128
In:
Bioorganic & medicinal chemistry letters vol. 13
Availability: No items available.
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12.
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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5). [electronic resource] by
- Callahan, James F
- Burgess, Joelle L
- Fornwald, James A
- Gaster, Laramie M
- Harling, John D
- Harrington, Frank P
- Heer, Jag
- Kwon, Chet
- Lehr, Ruth
- Mathur, A
- Olson, Barbara A
- Weinstock, Joseph
- Laping, Nicholas J
Producer: 20020325
In:
Journal of medicinal chemistry vol. 45
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13.
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Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. [electronic resource] by
- Harling, John D
- Deakin, Angela M
- Campos, Sébastien
- Grimley, Rachel
- Chaudry, Laiq
- Nye, Catherine
- Polyakova, Oxana
- Bessant, Christina M
- Barton, Nick
- Somers, Don
- Barrett, John
- Graves, Rebecca H
- Hanns, Laura
- Kerr, William J
- Solari, Roberto
Producer: 20131224
In:
The Journal of biological chemistry vol. 288
Availability: No items available.
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14.
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(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. [electronic resource] by
- Bamford, Mark J
- Alberti, Michael J
- Bailey, Nicholas
- Davies, Susannah
- Dean, David K
- Gaiba, Alessandra
- Garland, Stephen
- Harling, John D
- Jung, David K
- Panchal, Terence A
- Parr, Christopher A
- Steadman, Jon G
- Takle, Andrew K
- Townsend, James T
- Wilson, David M
- Witherington, Jason
Producer: 20051219
In:
Bioorganic & medicinal chemistry letters vol. 15
Availability: No items available.
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15.
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Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy. [electronic resource] by
- Alder, Catherine M
- Ambler, Martin
- Campbell, Amanda J
- Champigny, Aurelie C
- Deakin, Angela M
- Harling, John D
- Harris, Carol A
- Longstaff, Tim
- Lynn, Sean
- Maxwell, Aoife C
- Mooney, Chris J
- Scullion, Callum
- Singh, Onkar M P
- Smith, Ian E D
- Somers, Donald O
- Tame, Christopher J
- Wayne, Gareth
- Wilson, Caroline
- Woolven, James M
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 4
Availability: No items available.
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16.
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Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2. [electronic resource] by
- Mares, Alina
- Miah, Afjal H
- Smith, Ian E D
- Rackham, Mark
- Thawani, Aditya R
- Cryan, Jenni
- Haile, Pamela A
- Votta, Bartholomew J
- Beal, Allison M
- Capriotti, Carol
- Reilly, Michael A
- Fisher, Don T
- Zinn, Nico
- Bantscheff, Marcus
- MacDonald, Thomas T
- Vossenkamper, Anna
- Dace, Phoebe
- Churcher, Ian
- Benowitz, Andrew B
- Watt, Gillian
- Denyer, Jane
- Scott-Stevens, Paul
- Harling, John D
Producer: 20210615
In:
Communications biology vol. 3
Availability: No items available.
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17.
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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs. [electronic resource] by
- Watson, Nigel S
- Adams, Carl
- Belton, David
- Brown, David
- Burns-Kurtis, Cynthia L
- Chaudry, Laiq
- Chan, Chuen
- Convery, Máire A
- Davies, David E
- Exall, Anne M
- Harling, John D
- Irvine, Stephanie
- Irving, Wendy R
- Kleanthous, Savvas
- McLay, Iain M
- Pateman, Anthony J
- Patikis, Angela N
- Roethke, Theresa J
- Senger, Stefan
- Stelman, Gary J
- Toomey, John R
- West, Robert I
- Whittaker, Caroline
- Zhou, Ping
- Young, Robert J
Producer: 20110705
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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18.
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs. [electronic resource] by
- Young, Robert J
- Adams, Carl
- Blows, Mike
- Brown, David
- Burns-Kurtis, Cynthia L
- Chan, Chuen
- Chaudry, Laiq
- Convery, Máire A
- Davies, David E
- Exall, Anne M
- Foster, Graham
- Harling, John D
- Hortense, Eric
- Irvine, Stephanie
- Irving, Wendy R
- Jackson, Steve
- Kleanthous, Savvas
- Pateman, Anthony J
- Patikis, Angela N
- Roethka, Theresa J
- Senger, Stefan
- Stelman, Gary J
- Toomey, John R
- West, Robert I
- Whittaker, Caroline
- Zhou, Ping
- Watson, Nigel S
Producer: 20110705
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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19.
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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs. [electronic resource] by
- Kleanthous, Savvas
- Borthwick, Alan D
- Brown, David
- Burns-Kurtis, Cynthia L
- Campbell, Matthew
- Chaudry, Laiq
- Chan, Chuen
- Clarte, Marie-Olive
- Convery, Máire A
- Harling, John D
- Hortense, Eric
- Irving, Wendy R
- Irvine, Stephanie
- Pateman, Anthony J
- Patikis, Angela N
- Pinto, Ivan L
- Pollard, Derek R
- Roethka, Theresa J
- Senger, Stefan
- Shah, Gita P
- Stelman, Gary J
- Toomey, John R
- Watson, Nigel S
- West, Robert I
- Whittaker, Caroline
- Zhou, Ping
- Young, Robert J
Producer: 20100420
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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20.
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Catalytic in vivo protein knockdown by small-molecule PROTACs. [electronic resource] by
- Bondeson, Daniel P
- Mares, Alina
- Smith, Ian E D
- Ko, Eunhwa
- Campos, Sebastien
- Miah, Afjal H
- Mulholland, Katie E
- Routly, Natasha
- Buckley, Dennis L
- Gustafson, Jeffrey L
- Zinn, Nico
- Grandi, Paola
- Shimamura, Satoko
- Bergamini, Giovanna
- Faelth-Savitski, Maria
- Bantscheff, Marcus
- Cox, Carly
- Gordon, Deborah A
- Willard, Ryan R
- Flanagan, John J
- Casillas, Linda N
- Votta, Bartholomew J
- den Besten, Willem
- Famm, Kristoffer
- Kruidenier, Laurens
- Carter, Paul S
- Harling, John D
- Churcher, Ian
- Crews, Craig M
Producer: 20151009
In:
Nature chemical biology vol. 11
Availability: No items available.
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