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Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity. [electronic resource] by
- Hargrove, Tatiana Y
- Wawrzak, Zdzislaw
- Alexander, Paul W
- Chaplin, Jason H
- Keenan, Martine
- Charman, Susan A
- Perez, Catherine J
- Waterman, Michael R
- Chatelain, Eric
- Lepesheva, Galina I
Producer: 20131231
In:
The Journal of biological chemistry vol. 288
Availability: No items available.
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13.
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Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. [electronic resource] by
- Friggeri, Laura
- Hargrove, Tatiana Y
- Wawrzak, Zdzislaw
- Blobaum, Anna L
- Rachakonda, Girish
- Lindsley, Craig W
- Villalta, Fernando
- Nes, W David
- Botta, Maurizio
- Guengerich, F Peter
- Lepesheva, Galina I
Producer: 20190607
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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14.
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Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14α-demethylase: two regions of the enzyme molecule potentiate its inhibition. [electronic resource] by
- Friggeri, Laura
- Hargrove, Tatiana Y
- Rachakonda, Girish
- Williams, Amanda D
- Wawrzak, Zdzislaw
- Di Santo, Roberto
- De Vita, Daniela
- Waterman, Michael R
- Tortorella, Silvano
- Villalta, Fernando
- Lepesheva, Galina I
Producer: 20150207
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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15.
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Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. [electronic resource] by
- Lepesheva, Galina I
- Park, Hee-Won
- Hargrove, Tatiana Y
- Vanhollebeke, Benoit
- Wawrzak, Zdzislaw
- Harp, Joel M
- Sundaramoorthy, Munirathinam
- Nes, W David
- Pays, Etienne
- Chaudhuri, Minu
- Villalta, Fernando
- Waterman, Michael R
Producer: 20100208
In:
The Journal of biological chemistry vol. 285
Availability: No items available.
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16.
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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds. [electronic resource] by
- Hargrove, Tatiana Y
- Kim, Kwangho
- de Nazaré Correia Soeiro, Maria
- da Silva, Cristiane França
- Batista, Denise da Gama Jaen
- Batista, Marcos Meuser
- Yazlovitskaya, Eugenia M
- Waterman, Michael R
- Sulikowski, Gary A
- Lepesheva, Galina I
Publication details: International journal for parasitology. Drugs and drug resistance Dec 2012
In:
International journal for parasitology. Drugs and drug resistance vol. 2
Availability: No items available.
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17.
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Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase. [electronic resource] by
- Konkle, Mary E
- Hargrove, Tatiana Y
- Kleshchenko, Yuliya Y
- von Kries, Jens P
- Ridenour, Whitney
- Uddin, Md Jashim
- Caprioli, Richard M
- Marnett, Lawrence J
- Nes, W David
- Villalta, Fernando
- Waterman, Michael R
- Lepesheva, Galina I
Producer: 20090602
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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18.
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Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi. [electronic resource] by
- Hoekstra, William J
- Hargrove, Tatiana Y
- Wawrzak, Zdzislaw
- da Gama Jaen Batista, Denise
- da Silva, Cristiane F
- Nefertiti, Aline S G
- Rachakonda, Girish
- Schotzinger, Robert J
- Villalta, Fernando
- Soeiro, Maria de Nazaré C
- Lepesheva, Galina I
Producer: 20161107
In:
Antimicrobial agents and chemotherapy vol. 60
Availability: No items available.
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19.
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VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. [electronic resource] by
- Lepesheva, Galina I
- Hargrove, Tatiana Y
- Rachakonda, Girish
- Wawrzak, Zdzislaw
- Pomel, Sébastien
- Cojean, Sandrine
- Nde, Pius N
- Nes, W David
- Locuson, Charles W
- Calcutt, M Wade
- Waterman, Michael R
- Daniels, J Scott
- Loiseau, Philippe M
- Villalta, Fernando
Producer: 20160126
In:
The Journal of infectious diseases vol. 212
Availability: No items available.
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20.
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Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. [electronic resource] by
- Friggeri, Laura
- Hargrove, Tatiana Y
- Rachakonda, Girish
- Blobaum, Anna L
- Fisher, Paxtyn
- de Oliveira, Gabriel Melo
- da Silva, Cristiane França
- Soeiro, Maria de Nazaré C
- Nes, W David
- Lindsley, Craig W
- Villalta, Fernando
- Guengerich, F Peter
- Lepesheva, Galina I
Producer: 20190930
In:
Journal of medicinal chemistry vol. 61
Availability: No items available.
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