Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo. [electronic resource]
Producer: 20061030Description: 1017-27 p. digitalISSN:- 0887-6924
- Administration, Oral
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Boronic Acids -- administration & dosage
- Bortezomib
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Activation -- drug effects
- HSP27 Heat-Shock Proteins
- Heat-Shock Proteins -- drug effects
- Humans
- In Vitro Techniques
- Indoles -- administration & dosage
- Injections, Intravenous
- Leupeptins -- pharmacology
- Mice
- Mice, Nude
- Mitogen-Activated Protein Kinase 14 -- antagonists & inhibitors
- Molecular Chaperones
- Multiple Myeloma -- enzymology
- Neoplasm Proteins -- drug effects
- Protease Inhibitors -- administration & dosage
- Pyrazines -- administration & dosage
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- drug effects
- Xenograft Model Antitumor Assays
- bcl-X Protein -- drug effects
No physical items for this record
Publication Type: Comparative Study; Journal Article
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