Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. [electronic resource]
Producer: 20090224Description: 301-305 p. digitalISSN:- 0021-9258
- Amino Acid Substitution
- Arginine -- chemistry
- Crystallography, X-Ray
- Dinoprost -- chemistry
- Humans
- Intramolecular Oxidoreductases -- chemistry
- Microsomes -- enzymology
- Models, Molecular
- Mutation, Missense
- Oxidoreductases -- chemistry
- Prostaglandin H2 -- chemistry
- Prostaglandin-E Synthases
- Protein Structure, Tertiary -- genetics
- Structural Homology, Protein
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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